Metabolic Syndrome in Patients With First-episode Schizophrenia

Completed

• Conditions: Metabolic Syndrome X; Schizophrenia

• Registration Number: NCT00957294
• Lead Sponsor: Aarhus University Hospital

Brief Summary

The metabolic syndrome (MetS) is highly prevalent in patients with schizophrenia and is a major risk factor of type-2 diabetes, cardiovascular disease and early death. Genetic factors, antipsychotic medication, sleeping disturbances and unhealthy lifestyle are possible causes of developing metabolic syndrome. Several studies have investigated the metabolic side-effects of antipsychotic medication. However it is still unanswered how unhealthy lifestyle, comprising physical inactivity, smoking, unhealthy dieting, and sleeping disturbances adds to the metabolic risk of patients with schizophrenia. The aim of this study is to investigate the prevalence and development of MetS in first-episode patients with schizophrenia and 1 year after onset of treatment. The study's main hypothesis is that physical inactivity, regardless of medication, is an independent risk factor for metabolic syndrome in patients with schizophrenia. In comparison inpatients with major depression and healthy controls, both matched on gender, age and level of education will be included in the study. It is anticipated that the study's results will provide new knowledge about the risk of developing metabolic syndrome in first-episode schizophrenia and how different risk factors contribute to this.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-08
• Study First Submitted: 2009-08-03
• Study First Submitted QC: 2009-08-11
• Study First Posted: 2009-08-12
• Status Verified: 2012-03
• Primary Completion: 2013-04
• Study Completion: 2013-04
• Last Update Submitted: 2014-12-02
• Last Update Posted: 2014-12-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 203

Inclusion Criteria

• Patients with ICD-10 diagnosed schizophrenia

Exclusion Criteria

• Antipsychotic medication > 6 weeks before inclusion
• Physical disability
• Pregnancy
• IQ< 55

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
metabolic syndrome	1 year

Trial Locations

Locations (1)

Research Unit, Dep. Q of Affective Disorders, Aarhus University Hospital, Risskov; 🇩🇰 Aarhus, Risskov, Denmark