NL-OMON44557已完成4 期
Handling oxygenation targets in adults with acute hypoxaemic respiratory failure in the intensive care unit: A randomised clinical trial of a lower versus a higher oxygenation target - HOT-ICU trial
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 100
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •* Acutely admitted to the ICU AND
- •* Aged * 18 years AND
- •* Receives supplemental oxygen with a flow of at least 10 L per minutes in an open system including high-flow systems OR at least a FiO2 of 0.50 in a closed system including invasive or non-invasive ventilation or CPAP systems AND
- •* Expected to receive supplemental oxygen for at least 24 hours in the ICU AND
- •* Having an arterial line for PaO2 monitoring
排除标准
- •* Cannot be randomised within twelve hours after present ICU admission
- •* Chronic mechanical ventilation for any reason
- •* Use of home oxygen
- •* Previous treatment with bleomycin
- •* Organ transplant during current hospital admission
- •* Withdrawal from active therapy or brain death deemed imminent
- •* Fertile woman (< 50 years of age) with positive urine human gonadotropin (hCG) or plasma-hCG
- •* Carbon monoxide poisoning
- •* Cyanide poisoning
- •* Methaemoglobinaemia
- •* Paraquat poisoning
- •* Any condition expected to involve the use of hyperbaric oxygen (HBO)
- •* Sickle cell disease
- •* Consent not obtainable according to national regulations
- •* Previously randomised into the HOT-ICU trial
研究者
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