Dynamic hyperinflation during activities of daily living in patients with mild COPD.

• Conditions: chronic airflow limitation; chronic obstructive pulmonary disease (COPD); 10038716

• Registration Number: NL-OMON36962
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 88

Inclusion Criteria

Patients: Clinically stable COPD patients with GOLD I (=mild COPD, a FEV1/VC ratio (forced expiratory volume in one second divided by the vital capacity) < 0,7 and FEV1 >= 80% of predicted)and >= 18 years old.
Controls: Subjects with normal lung function and with similar ages and gender distribution as the patients with COPD

Exclusion Criteria

Patients: patients with long term oxygen therapy at home, with co-existing lung disease other than COPD (including asthma), with restrictive lung function, with other exercise-limiting disorders than COPD like cardiac or neuromuscular disease, or patients using β-blockers are excluded from the study.
Controls: subjects with abnormal lung function or history of lung disease or with exercise-limiting disorders like cardiac or neuromuscular disease are excluded from the study.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>For the first objective, the main study parameter is the percentage of subjects<br /><br>that show dynamic hyperinflation during ADL.<br /><br>For the second objective, the main study parameter is the difference in dynamic<br /><br>hyperinflation during ADL between baseline and after two years of follow-up.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Measured during ADL:<br /><br>Ventilatory parameters: ventilation (Ve), breathing reserve (BR), Ve/maximal<br /><br>ventilatory capacity (MVC), ventilatory equivalent for CO2 (Ve/VCO2), partial<br /><br>pressure of end-tidal CO2 (PetCO2), breathing frequency (BF).<br /><br>Operational lung volumes: inspiratory reserve volume (IRV), tidal volume (Vt)<br /><br>Cardiovascular parameters: heart rate (HR), HR reserve, O2-pulse, blood<br /><br>pressure<br /><br>Other: oxygen consumption (VO2), dyspnea, ADL-time, gas exchange</p><br>