Evaluation of Guided Endodontic Microsurgery and Two Different Retrograde Filling Materials

Not Applicable

Completed

• Conditions: Endodontic Re-treatment Failure
• Interventions: Drug: MTA retrograde filling; Drug: well root putty ( premixed bioceramic putty) retrograde filling

• Registration Number: NCT07184151
• Lead Sponsor: Suez Canal University

Brief Summary

The aim of this study was to evaluate the effect of guided endodontic microsurgical root end resection on bone healing compared to nonguided microsurgery using two different retrograde filling material (Well root putty, MTA) by cone-beam computed tomography.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-01-20
• Primary Completion: 2023-08-12
• Study Completion: 2024-04-15
• Status Verified: 2025-09
• Study First Submitted: 2025-09-13
• Study First Submitted QC: 2025-09-13
• Last Update Submitted: 2025-09-13
• Study First Posted: 2025-09-19
• Last Update Posted: 2025-09-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Tooth is restorable pocket depth is less than 4mm and mobility in its normal limit ( less than 1mm)
• Persisting or emerging disease following root-canal treatment when root canal re-treatment is inappropriate.
• Tooth with acceptable endodontic treatment and have a new post and crown restoration, but have a persistent or enlarging periapical lesion ( size less than 10 mm)
• Obstructed canal (the obstruction proved not to be removable, by passed and the risk of damage was too great).
• Extruded material or instrument with clinical or radiological findings of apical periodontitis and/or symptoms are present.

Exclusion Criteria

• Non restorable tooth
• Contraindicating medical condition ( severe systemic condition and psychological condition)
• Anatomical contra indication
• Poor general oral status and supporting periodontal tissue.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
microsurgical apicoectomy without guide+MTA	MTA retrograde filling	-
microsurgical apicoectomy without guide+well root putty ( premixed bioceramic putty) retrograde fil	well root putty ( premixed bioceramic putty) retrograde filling	-
microsurgical apicoectomy with guide+MTA	MTA retrograde filling	-
microsurgical apicoectomy with guide+well root putty ( premixed bioceramic putty) retrograde fil	well root putty ( premixed bioceramic putty) retrograde filling	-

Primary Outcome Measures

Name	Time	Method
Change in bone density measurement over time	1 week, 6 months

Secondary Outcome Measures

Name	Time	Method
Operating time	once
Pain (VAS scale)	1 week, 6 months

Trial Locations

Locations (1)

Faculty of Dentistry, Suez Canal University; 🇪🇬 Ismailia, Egypt