In vitro drug-free activation (IVA) of the ovarian cortex and its re-transplantation in infertile women with reduced ovarian reserve
Phase 2
- Conditions
- Infertile women with reduced ovarian reserve.Female infertility
- Registration Number
- IRCT20221016056198N3
- Lead Sponsor
- Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 15
Inclusion Criteria
Patients with age less than 40 years had decreased ovarian reserve based on POSEIDON group 3 and 4 criteria
AMH less than 1 mg/dl
Fsh less than 10
with a history of at least one failed stimulation cycle resulting in the inability to retrieve oocyte
Exclusion Criteria
male factor infertility
positive history of hydrosalpinx
anatomical uterine disorders
endocrine disease
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The count of retrieved oocytes. Timepoint: 3 months after IVA. Method of measurement: microscopic.;The count of metaphase II oocytes. Timepoint: 3 months after IVA. Method of measurement: microscopic.
- Secondary Outcome Measures
Name Time Method Quantity of embryos transferred. Timepoint: 6 day after stimulation. Method of measurement: microscopic.;Implantation rate. Timepoint: 5 weeks after transfer. Method of measurement: tvs sonography.;Clinical pregnancy rate. Timepoint: 5 weeks after transfer. Method of measurement: tvs sonography.;Number of embryos transferred. Timepoint: 6 day after stimulation. Method of measurement: microscopic.