Changes in the immunomodulatory properties of Adipose Stromal cells due to Hemarthrosis after knee injury

Recruiting

Conditions: 10023213
post-traumatic arthrosis
post-traumatic osteoarthritis

Registration Number: NL-OMON50890

Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 20

Inclusion Criteria

10 patients with hemarthrosis
10 patients without hemarthrosis

-18 years or older
-Recently suffered an injury of the index knee (rotational or hyperextension)
-A swollen kneejoint
-Inability to mobilise

Exclusion Criteria

- Patients with an active inflammatory or infectious comorbid disease
(including rheumatic diseases)
- Patients with knee prosthesis
- Patients with coagulation disorders
- Patients with a history of a cruciate ligament or meniscal injury of the
index knee
- Patients with a tibiofemoral fracture due to current distorsion

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The anti-inflammatory capacities of ASC*s in synovial fluid that contains blood<br /><br>as a result of hemarthrosis after knee injury compared to the anti-inflammatory<br /><br>capacities of ASC's in synovial fluid that does not contain blood. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- The natural course of pro-inflammatory factors levels and hemarthrosis<br /><br>related factor levels in the first weeks after trauma<br /><br><br /><br>- The correlation between pro-inflammatory factors and hemarthrosis<br /><br><br /><br>- The correlation between levels of pro-inflammatory factor levels and<br /><br>hemarthrosis related factor levels with the clinical presentation on the<br /><br>endpoints: swelling, pain and function impairment </p><br>