Effectiveness of Intercostal Tube Drainage Vs Pigtail Catheter Drainage Vs Ultrasound-Guided Aspiration in Management of Massive Malignant Pleural Effusion
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 66
- 主要终点
- Resolution of Pleural Effusion
研究概览
简要总结
Pleural effusion is common in different diseases and especially malignant effusions can have fast onset symptoms such as chest pain, dyspnoea, and coughing. Malignant pleural effusion (MPE) is an exudative effusion with malignant cells.
It is a common symptom and accompanying presentation of metastatic disease. It Impacts up to 15% of all patients with cancer and is the most common in breast, lung, cancer, lymphoma, and gynaecological malignancies . There are 150,000 new cases of MPE in the United States yearly and 100,000 in Europe . Patients have an overall survival (OS) rate of 3-12 months after the initial diagnosis . Malignant pleural effusion (MPE) poses significant challenges in management, impacting patient quality of life and overall prognosis. Almost all radiological procedures can help diagnose pleural effusions . Thoracentesis is used as a diagnostic and therapeutic tool. The procedure has been modified with the addition of ultrasound, that is very functional for targeting certain anatomical areas of the pleura and finding an appropriate entry point . Three primary strategies are commonly employed: intercostal tube drainage, big tail catheter drainage, and ultrasound-guided aspiration. This study aims to evaluate these methods' efficacy, safety, and outcomes. To compare intercostal tube drainage, big tail catheter drainage, and ultrasound-guided aspiration in managing massive malignant pleural effusion (MPE).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patient aged 18 years old and above.
- •Patients diagnosed with massive malignant pleural effusion (MPE) requiring intervention.
排除标准
- •Pediatric patients aged below 18 years
- •Patients with non-malignant causes of pleural effusion.
研究组 & 干预措施
Group A
intercostal tube drainage in managing massive malignant pleural effusion (MPE).
干预措施: intercostal tube drainage (Procedure)
Group B
big tail catheter drainage in managing massive malignant pleural effusion (MPE).
干预措施: big tail catheter drainage (Procedure)
Group C
ultrasound-guided aspiration in managing massive malignant pleural effusion (MPE).
干预措施: ultrasound-guided aspiration (Procedure)
结局指标
主要结局
Resolution of Pleural Effusion
时间窗: baseline
Resolution of Pleural Effusion: Defined as complete or partial resolution based on imaging studies (e.g., chest X-ray or ultrasound).
次要结局
未报告次要终点
研究者
Mark Badrat William Mansour
residant doctor
Assiut University
