Three-dimensional analysis of hemodynamic wall parameters in the carotid bifurcation using computer-augmented 4D flow MRI
Recruiting
- Conditions
- I65.2I10-I15Occlusion and stenosis of carotid arteryHypertensive diseases
- Registration Number
- DRKS00025543
- Lead Sponsor
- niversitätsklinikum Freiburg
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
>/= 90 years of age
- asymptomatic 20-80% ICA stenosis (NASCET criteria)
- one additional cardiovascular risk factor (hypertension, smoking habit, diabetes mellitus, hyperlipidemia, peripheral artery disease, coronary heart disease, familial predisposition)
Exclusion Criteria
- lack of ability to consent
- refusal of study participation
- contraindications against 3 Tesla MRI (such as ferromagnetic implants, claustrophobia)
- bad clinical condition (modified ranking scale >3)
- atrial fibrillation or other relevant cardiac arrhythmias due to the interference with the ECG-trigger during 4D flow MRI
- expectation of life <2 years
- distance to place of residence >100 kilometers
- scheduled carotid artery endarterectomy
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Identification of independent predictors of of a) progression of carotid artery atherosclerosis and b) cerebrovascular events (cerebral or retinal ischemia) using 4D flow MRI and 4D flow MRI in conjunction with computer-augmentation (wall shear stress, plaque surface pressure, oscillatory shear index)
- Secondary Outcome Measures
Name Time Method