Clinical Biological and Pharmacological Factors Influencing Stroke Outcome

Completed

• Conditions: Stroke

• Registration Number: NCT00763217
• Lead Sponsor: University Hospital, Lille

Brief Summary

In a previous suty, we have demonstrated that prior transient ischemic attack, treatment lipid-lowering drug or physical activity are associated to a better outcome of stroke. The aim of the study is to understand the mechanisms of this preventive neuroprotection by establishing link between biomarkers and preventive and neuroprotective measures.To answer to the question, we conduct a cohort study of stroke patients.

Detailed Description

In the cohort, the severity of stroke (NIHSS) will be correlated with :

* clinical factors,

* pharmacological factors,

* biological factors (inflammatory markers, hemostasis...)

Study Timeline

• Study Start: 2005-06
• Study First Submitted: 2008-09-26
• Study First Submitted QC: 2008-09-29
• Study First Posted: 2008-09-30
• Primary Completion: 2009-06
• Study Completion: 2012-06
• Status Verified: 2015-05
• Last Update Submitted: 2015-05-12
• Last Update Posted: 2015-05-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 550

Inclusion Criteria

• ischemic or hemorrhage stroke
• hemispheric stroke
• stroke dating from less 48h

Exclusion Criteria

• non hemispheric stroke
• malformative intracranial hemorrhage
• traumatic intracranial hemorrhage
• subarachnoidal hemorrhage

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
severity of stroke measured by NIH severity score	inclusion, day7, month3, year3

Secondary Outcome Measures

Name	Time	Method
clinical, pharmacological and biological (metabolic, inflammation, hemostasis...) cognitive status	inclusion and year3

Trial Locations

Locations (1)

Lille University Hospital - Service de Neurologie vasculaire; 🇫🇷 Lille, France