Is glycine absorbed in critical illness and can it prevent muscle loss?

Not Applicable

Active, not recruiting

Conditions: Musculoskeletal - Other muscular and skeletal disorders
Critical illness
Muscle wasting and weakness
Enteral glycine absorption
Diet and Nutrition - Other diet and nutrition disorders

Registration Number: ACTRN12618000409279

Lead Sponsor: Royal Melbourne Hospital

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Active, not recruiting

Sex: All

Target Recruitment: 29

Inclusion Criteria

a.Aged 18 years or over
b.Receiving invasive mechanical ventilation and expected to remain mechanically ventilated until the day after tomorrow
c.Arterial or central venous line in situ
d.Receiving or suitable to receive EN
e.Expected to be receiving EN in the ICU until at least the day after tomorrow

Exclusion Criteria

a.Death during ICU admission deemed to be inevitable
b.Pregnancy
c.Lower limbs amputated
d.Spinal cord injury
e.Presented with primary neuromuscular pathology
f.Presented with disseminated cancer
g.Bleeding diathesis (corrected INR > 1.5 and/or APTT > 50), or receiving anticoagulants beyond that required for venous thromboembolism prophylaxis or antiplatelet drugs other than aspirin
h.Received > 72 hours of EN or PN during this ICU admission
i.Intolerant of EN (gastric residual volume > 300mL)
j.Already been admitted to ICU for > 96 hours during this hospitalization
k.Previously enrolled in this study
l.Requirement for specific nutritional therapy as determined by the treating doctor or dietitian

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Glycine absorption following administration of a test meal, measured as area under the plasma glycine concentration curve, where plasma glycine will be measured using high-performance liquid chromatography[ Measured at baseline and thirty minutely for four hours post-test meal]

Secondary Outcome Measures