Evaluation and Monitoring of the Protocol Post Operative Atrial Fibrillation

Completed

• Conditions: Post Operative Atrial Fibrillation

• Registration Number: NCT05165862
• Lead Sponsor: University Hospital, Brest

Brief Summary

Objectives The aims of this study is to evaluate the efficacy and tolerance of our post-operative AF management protocol after cardiac surgery, including beta-blockers, digoxin, amiodarone.

Methods This study concerns patients From brest university Hospital who underwent cardiac surgery between November 2019 and November 2021. Patients with a previous history of atrial arrhythmias were excluded. The primary endpoint is assess effectiveness of service protocol to maintain cardiac frequency below. 110 bpm. The secondary endpoints included hemodynamic tolerance and outcomes.

Detailed Description

Background Atrial fibrillation (AF) is the most common complication after open heart surgery. Its reported incidence is about 30%, and it is associated with a significant increase rate of thromboembolic events, respiratory failure, a longer lenght of stay in hospital and mortality. (1 ;2) Gillinov's study has shown equivalent effectiveness of a rhythm control and rate control strategy, in AF patients after cardiac surgery, with increased side effects in patients treated with rhythm control agents. (3) The introduction of beta-blockers can be poorly tolerated hemodynamically in patients hospitalized in intensive care unit, unless untroducing a cardio-selective beta-blocker..

Methods Patients who underwent a cardiac surgery from Novembre 2019 to Novembre 2021 were included. Patients with a previous history of atrial arrhythmias were excluded. The primary endpoint is assess effectiveness of service protocol to maintain cardiac frequency below. 110 bpm. The secondary endpoints included hemodynamic tolerance and outcomes.

Study Timeline

• Study Start: 2020-02-01
• Study First Submitted: 2020-09-24
• Primary Completion: 2021-10-16
• Study Completion: 2021-10-16
• Status Verified: 2021-12
• Study First Submitted QC: 2021-12-14
• Last Update Submitted: 2021-12-14
• Study First Posted: 2021-12-21
• Last Update Posted: 2021-12-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 54

Inclusion Criteria

• POAF after cardiac surgery non-opposition formulated

Exclusion Criteria

• pregnant woman opposition hemodynamic unstability with inotropic drugs or CI<2 L/min/m2

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Heart Rate	72 hours (3 days)	HR \< 110 BPM

Secondary Outcome Measures

Name	Time	Method
sinusal Rythm	72hours ( 3 days)	time to be back in sinusal rythm

Trial Locations

Locations (1)

CHRU de Brest - Service d'anesthésie-Réanimation; 🇫🇷 Brest, France