Comparing two surfactant administration techniques to know which technique has better outcome result.
- Conditions
- Health Condition 1: J981- Pulmonary collapse
- Registration Number
- CTRI/2021/06/033944
- Lead Sponsor
- Pushpender Singh Mehra
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
1)Preterm 28-36 weeks
2)Requirement of nasal continues airway pressure(ncpap) level beyond or equal to 5cm of water and fiO2 greater or equal to o. 30 to maintain sPO2 of 88-92%.
3)Requirement of nasal high flow nasal canula(NHHHFNC) level beyond or equal to 5L/min cm of water and fiO2 greater or equal to 0.3 to maintain sPO2 of 88-92%.
4)Requirement of free flow O2 to 2L/min cm of water and fiO2 greater or equal to 0.3 to maintain sPO2 of 88-92%.
1)Severe respiratory distress syndrome with high oxygen requirement and or severe respiratory acidocissuch that ventilatory support will be necessary after surfactant therapy, suggested FiO2 threshold at which intubation for surfactant will be considered is >60(lower threshold)
2)Pulmonary hypoplasia
3)Cyanotic heart disease
4)Antinatally diagnosed congenital lung anomalies
5)Requirement intubation for resuscitation at birth
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method eed for mechanical ventilation in first 72 hours in preterm newborns with RDS administered surfactant by LISA and INSURE.Timepoint: Birth till first 72 hours
- Secondary Outcome Measures
Name Time Method Duration of mechanical ventilation needed between LISA and INSURE group <br/ ><br>Duration of hospital stay between the LISA AND INSURE group <br/ ><br>Need for supplement O2 between LISA and INSURE group.Timepoint: Birth till first 12 hours