A Prospective Observational Study on Pulmonary Hypertension in Patients With Obstructive Sleep Apnea: Correlation of Apnea-Hypopnea Severity With Pulmonary Artery Pressures
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 55
- 主要终点
- Mean Pulmonary Artery Pressure
研究概览
简要总结
This study investigates the association between obstructive sleep apnea (OSA) and pulmonary hypertension (PH), focusing on the relationship between OSA severity and pulmonary arterial pressures in adult patients.
详细描述
This prospective, observational, cross-sectional study will be conducted in the pulmonology and sleep medicine departments of Assiut University. Patients diagnosed with OSA through overnight polysomnography will be assessed for the presence and severity of PH using echocardiography. The study aims to determine whether OSA serves as an independent risk factor for PH and whether the severity of OSA, as measured by apnea-hypopnea index (AHI) and oxygen desaturation index (ODI), correlates with echocardiographic indicators of PH. Data will be analyzed using standardized statistical methods to establish links between OSA severity and hemodynamic changes.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults aged 18-65 years
- •Diagnosed with obstructive sleep apnea (OSA) by full-night polysomnography
- •Apnea-Hypopnea Index (AHI) ≥ 5 events/hour
排除标准
- •Secondary pulmonary hypertension due to:Chronic pulmonary diseases, Left ventricular heart disease and Chronic thromboembolic disorders
- •Use of pulmonary vasodilator therapy
- •Long-term oxygen therapy (LTOT)
- •Respiratory neuromuscular weakness
- •Chest wall deformities
- •End-organ failure (cardiac, renal, hepatic)
- •Obesity hypoventilation syndrome
结局指标
主要结局
Mean Pulmonary Artery Pressure
时间窗: baseline
The primary objective is to assess the presence and degree of pulmonary hypertension (measured by echocardiography) in OSA patients.
次要结局
未报告次要终点
研究者
Ashraqat Tony Badawy
resident at the of Chest Diseases department
Assiut University