METHODS - A randomised controlled trial of METhotrexate to treat Hand Osteoarthritiswith Synovitis

Monash University0 个研究点目标入组 97 人开始时间: 2017年6月15日最近更新: 2022年8月9日

试验速览

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•1. Aged 40 - 75 years with symptomatic radiological hand osteoarthritis and synovitis
•2. A pain score of greater than or equal to 40mm on a 100mm visual analogue scale and radiological osteoarthritis (Kellgren and Lawrence grade greater than or equal to 2) in at least one joint
•3. Evidence of synovitis determined from magnetic resonance imaging with a grade greater than or equal to 1 in at least one joint

•1. Concomitant rheumatic disease, inflammatory joint disease, psoriatic arthritis, ankylosing spondylitis, or gout
•2. Contraindication to methotrexate (e.g. renal, liver or haematological condition, cancer including skin cancer, serious infections requiring hospitalisation in the last 5 years, known or past infection with HIV, Hepatitis B or C, Tuberculosis, or known lung disease with scarring (any fibrosis or evidence of past tuberculosis exposure on chest x-ray), concurrent regular prednisolone use, taking regular Trimethoprim or Bactrim antibiotics, egg or flu vaccination allergy, women who are pregnant, breast-feeding or trying to become pregnant, or men who father a child)
•3. Contraindication to magnetic resonance imaging (e.g. implanted pacemaker, metal sutures, presence of shrapnel or iron filings in the eye, or claustrophobia)
•4. Unable to complete informed consent.

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