Investigating the Effects of Diet and Gut Microecology on Bone Health in Gannan Tibetan Elementary School Students
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 431
- 试验地点
- 1
- 主要终点
- Dietary Characteristics
研究概览
简要总结
The study aims to understand the current situation of bone health in the Gannan Tibetan primary school student population, to explore the relationship between nutrition, intestinal microorganisms and bone health, to analyze the main factors affecting bone health from the perspective of nutrition and intestinal microecology, and to provide theoretical basis for the promotion and improvement of bone health in Tibetan primary school students.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 6 Years 至 13 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Tibetan primary school students currently enrolled in schools in Gannan Tibetan Autonomous Prefecture;
- •Willing to participate and able to cooperate in completing bone density measurements;
- •Additional inclusion criteria: Subjects who are 9 years old or older and agree to participate in dietary surveys and fecal sampling.
排除标准
- •Use of corticosteroid medications within the past year;
- •Suffering from skeletal system diseases, metabolic disorders, or endocrine diseases;
- •Additional exclusion criteria: Subjects who have used antibiotics in the past three months and are undergoing fecal sampling.
结局指标
主要结局
Dietary Characteristics
时间窗: Day 1
Dietary data were collected using a food frequency questionnaire (FFQ) to analyze dietary patterns and nutrient intake.
Bone density test
时间窗: Day1
In this study, a peripheral dual-energy X-ray absorptiometry (EXA-PRESTO) was used to measure the bone density of the non-dominant forearm of the subjects.
Fecal sample microbiological testing and analysis
时间窗: Day 1
This study entrusted Tianhao Gene Technology Co., Ltd. to perform the intestinal microbiome Accu16STM (16S rRNA absolute quantitative sequencing). The main research processes include DNA extraction, PCR amplification, library construction, and sequencing.
次要结局
未报告次要终点
研究者
Jianhua Ma
Lecturer
LanZhou University