Comparison of Paracetamol and Dexketoprofen Trometamol on Headache Treatment After Electroconvulsive Treatment
Overview
- Phase
- Phase 4
- Intervention
- Paracetamol
- Conditions
- Mental Disorders
- Sponsor
- Mustafa Kemal University
- Enrollment
- 225
- Locations
- 1
- Primary Endpoint
- Headache (Visual Analogue Scale 0-10)
- Last Updated
- 7 years ago
Overview
Brief Summary
Electroconvulsive treatment (ECT) is still actual for treatment of psychiatric symptoms. Headache is a very common symptom after this application. The investigators compare the effect of two different drugs for the treatment of headache after ECT.
Detailed Description
Electroconvulsive treatment (ECT) is used as an alternative application instead of drug therapy for psychiatric symptoms. ECT application is repeated 8-12 times according to the treatment of the patient. This treatment is done in 2 or 3 days intervals. The most adverse effects of ECT are headache, memory disorders, myalgia, nausea and vomiting, cardiovascular problems. The most common seen adverse effect is headache with approximately 60% incidence. The main drugs used for the treatment of headache related to ECT are NSAIs and paracetamol. The aim of the current study is to compare the effect of paracetamol and dexketoprofen trometamol on headache treatment after ECT.
Investigators
Onur Koyuncu
Assoc.Prof.MD
Mustafa Kemal University
Eligibility Criteria
Inclusion Criteria
- •All patients who were admitted for ECT and gave informed written consent were included in the study.
Exclusion Criteria
- •Exclusion criteria included patients who gave a history of allergy to acetaminophen, lacked capacity to give informed consent and developed complications such as delirium following ECT.
Arms & Interventions
Paracetamol
Parol group: intravenous infusion in 30 min Generic name: Parol Dosage form: intravenous Dosage: 1 gr Frequency: preop one dose only Duration: For one week
Intervention: Paracetamol
Deksketoprofen trometamol
Sertofen group: intravenous infusion in 30 min Generic name: Sertofen Dosage form: intravenous Dosage: 50 mg Frequency: preop one dose only Duration: For one week
Intervention: Deksketoprofen trometamol
Placebo
Placebo group: intravenous infusion in 30 min Generic name: Serum physiologic Dosage form: intravenous Dosage: 100 ml Frequency: preop one dose only Duration: For one week
Intervention: Placebo
Outcomes
Primary Outcomes
Headache (Visual Analogue Scale 0-10)
Time Frame: Postoperative 2. hour, 4. hour, 6. hour (up to six hours after intervention)
Headache (VAS) change is being assessed in three different time frames after ECT
Secondary Outcomes
- Additive analgesic-antiemetic consumption(Postoperative 2. hour, 4. hour, 6. hour (up to six hours after intervention))
- Adverse effects (Nausea-Vomiting, bradycardia, hypotension)(Postoperative 2. hour, 4. hour, 6. hour (up to six hours after intervention))