Susceptibility to High Altitude Pulmonary Edema in Subjects With Increased Hypoxic Pulmonary Vasoconstriction
Not Applicable
Completed
- Conditions
- High Altitude Pulmonary Edema
- Registration Number
- NCT00559442
- Lead Sponsor
- Heidelberg University
- Brief Summary
It has been shown, that subjects susceptible to high altitude pulmonary edema (HAPE)are characterized by an abnormal increase of pulmonary artery pressure at rest in hypoxia and during exercise in normoxia. This abnormal rise of pulmonary artery pressure has also been observed in about 10 % of otherwise healthy subjects without prior altitude exposure. The aim of the study is to investigate the susceptibility to HAPE in unacclimatized subjects with abnormal increase of pulmonary artery pressure at rest in hypoxia and during exercise in normoxia after rapid ascent to high altitude (4559 m).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
- abnormal increase of pulmonary artery pressure at rest in hypoxia and during exercise in normoxia
- ability to climb Margherita Hut
Exclusion Criteria
- Birth at or above 1500 m altitude
- any cardiovascular or pulmonary disease
- Infection disease
- Intake of drugs, in particular Acetazolamide, Nifedipine, corticosteroids or PDE-5-inhibitors.
- Pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Frequency of HAPE after rapid ascent to 4559 m during the 48 h stay at altitude
- Secondary Outcome Measures
Name Time Method Time course of pulmonary artery pressure during the 48 h stay at altitude Assessment of right ventricular function by echocardiography during the 48 h stay at altitude
Trial Locations
- Locations (1)
Sports Medicine, University Hospital
🇩🇪Heidelberg, Germany