NCT01169805已完成不适用
Prophylactic Effects of Ondansetron, Ramosetron, and Palonosetron on Patient-Controlled Analgesia Related Nausea and Vomiting After Urologic Laparoscopic Surgery
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 105
- 试验地点
- 1
- 主要终点
- severity of nausea
研究概览
简要总结
The aim of this prospective randomized controlled study was to compare the prophylactic effects of intravenous single dose of ondansetron, ramosetron, and palonosetron on PCA-related nausea and vomiting after urologic laparoscopic surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Care Provider, Investigator)
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •ASA I or II
- •Patients aged (20-65 yr) Undergoing Laparoscopic Nephrectomy
- •Patients who want a patient-controlled IV analgesia (IV-PCA)
排除标准
- •History of allergy or hypersensitivity to 5-HT3 antagonist
- •History of severe postoperative nausea/vomiting
- •Prolonged QT interval on preoperative EKG
- •Hypokalemia, Hypomagnesemia
- •Intestinal obstruction
- •Pregnant female or breast feeding mother
研究组 & 干预措施
ONSERAN
Experimental
干预措施: Ondansetron (Drug)
NASEA
Experimental
干预措施: Ramosetron (Drug)
ALOXI
Experimental
干预措施: Palonosetron (Drug)
normal saline
Placebo Comparator
干预措施: Normal saline inj (Drug)
结局指标
主要结局
severity of nausea
时间窗: during 73 hours after surgery
the number of vomiting
时间窗: during 73 hours after surgery
次要结局
未报告次要终点
研究者
研究点 (1)
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