Prospective Observational Cohort Study
- Conditions
- Gastric CancerLiver Metastases
- Interventions
- Other: observation
- Registration Number
- NCT06493448
- Lead Sponsor
- Lin Chen
- Brief Summary
The goal of this observational study is to learn about the overall disease status, diagnostic and therapeutic modalities, and prognosis of patients with gastric cancer liver metastasis(GCLM) in China. The investigators divided the participants into three groups( three types) of gastric cancer liver metastasis based onChinese c-GCLM classification system.The main question it aims to answer is:
1. How long do patients with GCLM live?
2. How different treatment modalities (surgery, chemotherapy, immunotherapy, targeted therapy and others) affect patients' prognosis of three type? All participants will be tracked for their physical condition.
- Detailed Description
This is a prospective, non-interventional, observational, multi-centre, real-world study designed to monitor the general condition, treatment pattern and prognosis of patients with GCLM. GCLM patients were divided into 3 types: Type I (resectable type), Type II (potentially resectable type), Type III (unresectable type). The patients' general information, past medical history, imaging results, laboratory tests, surgical and systemic therapy details will be recorded and analysed. The 2-year overall survival (OS) will be recorded as the primary endpoint. The different therapies (surgery, chemotherapy and immunotherapy) of GCLM, the effects of different therapies on prognosis including OS of type I, II and III; R0 resection rate and diease free survival (DFS) of type I; successful conversion rate and R0 resection rate and events free survival (EFS) of type II will be recorded as secondary endpoints.
This study involving human participants were reviewed and approved by the Ethics Committee of Chinese PLA General Hospital (No.S2023-724-02) and will be conducted according to the guidelines of the Declaration of Helsinki. Study findings will be disseminated through international peer-reviewed journal articles as well as public, academic presentations at national and international conferences.
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 1326
- aged ≥18 years
- gastric primary lesions confirmed by pathology and liver metastases confirmed by pathology or imaging (before, during, or after initial treatment)
- expected survival time of ≥ 12 weeks
- Eastern Cooperative Oncology Group Physical Status Score (ECOG PS score) of 0-2
- signed informed consent
- good compliance and ability to complete regular follow-up
- heterochronous liver metastases
- multi-centra clinics with significant missing case information
- diagnosed, suspected or active autoimmune disease
- history of immunodeficiency
- history of allogeneic organ and haematopoietic stem cell transplantation
- pregnant or breastfeeding female patients
- uncontrolled co-morbidities, including but not limited to:
- a.HIV-infected (HIV-positive) patients
- b.severe infections that are active or poorly controlled clinically
- c.evidence of severe or uncontrolled systemic disease
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- severe psychiatric disease
-
- severe neurological disease
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- epilepsy
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- dementia
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- unstable or uncompensated respiratory
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- cardiovascular
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- hepatic disease
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- renal disease
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- uncontrolled hypertension
- Abnormal coagulation in people with active bleeding or new thrombotic disease, on therapeutic doses of anticoagulants, or with bleeding tendencies.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Cohort A observation Type I liver metastases, resectable type, with the option of direct surgical resection or preoperative systemic therapy Cohort B observation Type II liver metastases, potentially resectable type, preoperative systemic therapy is applied to gain the chance of surgery Cohort C observation Type III liver metastases, systemic treatment according to recommended guidelines and patient characteristics
- Primary Outcome Measures
Name Time Method 2-year OS 2 years OS from diagnosed time to measured time or death The primary study endpoint was two-year survival in patients
- Secondary Outcome Measures
Name Time Method OS of type II （questionnaires, phone calls, and outpatient follow-up.） OS from diagnosed time to measured time or death（2 to 5 years） the effects of different therapeutic modalities (surgery, chemotherapy, immunotherapy, targeted therapy and others) on prognosis.
R0 resection rate (pathological information from medical record.) Through study completion, an average of 2 year. Proportion of all operated patients achieving radical resection.
OS of type I（questionnaires, phone calls, and outpatient follow-up.） OS from diagnosed time to measured time or death（up to 5 years） the effects of different therapeutic modalities (surgery, chemotherapy, immunotherapy, targeted therapy and others) on prognosis.
successful conversion therapy rate (pathological information and surgery information from medical record.) Through study completion, an average of 2 year. Proportion of type II patients underwent radical surgery after systemic treatment.
DFS of type I（questionnaires, phone calls, and outpatient follow-up.） Through study completion, an average of 2 year. DFS of type I. Disease-free survival time maintained after the participant has been saved by therapeutic measures.Especially in patients underwent radical surgery.
OS of type III（questionnaires, phone calls, and outpatient follow-up.） OS from diagnosed time to measured time or death（no more than 2 years） the effects of different therapeutic modalities (surgery, chemotherapy, immunotherapy, targeted therapy and others) on prognosis.
Trial Locations
- Locations (1)
Chinese PLA General Hospital
🇨🇳Beijing, Beijing, China