Seoul National University Pituitary Disease Cohort Study

Recruiting

• Conditions: Central Diabetes Insipidus; Pituitary Incidentaloma; Prolactinoma; Pituitary Disease; Acromegaly; Pituitary Stalk Compression Hyperprolactinaemia; Cushing's Disease; Pituitary Tumor
• Interventions: Other: Dynamic hormone study and Magnetic resonance imaging

• Registration Number: NCT03474601
• Lead Sponsor: Seoul National University Hospital

Brief Summary

The purpose of this study is to investigate the treatment and natural history of pituitary disease. We have a longstanding interest in pituitary disease including acromegaly, central diabetes insipidus, and nonfunctioning pituitary adenoma. We will continue to follow patients and recruit new patients for treatment and follow-up. Blood and pituitary tumor tissue (when available through clinical care) will be saved for future analyses related to pituitary disease.

Detailed Description

Subjects for this study will be recruited if they are:

1. Adults, male or female aged 18 years or older

2. Have been diagnosed with pituitary diseases

Study Timeline

• Study Start: 2015-03-15
• Study First Submitted: 2018-03-10
• Study First Submitted QC: 2018-03-15
• Study First Posted: 2018-03-22
• Status Verified: 2019-03
• Last Update Submitted: 2020-03-17
• Last Update Posted: 2020-03-18
• Primary Completion: 2025-02-14
• Study Completion: 2025-02-14

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 1600

Inclusion Criteria

• Subjects for this study will be recruited if they are:

  1. Adults, male or female aged 18 years or older
  2. diagnosed with pituitary diseases such as acromegaly, Cushing's disease, hyperprolactinemia, nonfunctioning pituitary adenoma, pituitary stalk lesions, central diabetes insipidus, and craniopharyngiomas

Exclusion Criteria

• Patients who do not agree with the study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Nonfunctioning pituitary adenomas	Dynamic hormone study and Magnetic resonance imaging	Patients diagnosed with nonfunctioning pituitary adenomas
Acromegaly	Dynamic hormone study and Magnetic resonance imaging	Patients diagnosed with acromegaly
Central diabetes insipidus	Dynamic hormone study and Magnetic resonance imaging	Patients diagnosed with central diabetes insipidus
Pituitary stalk lesions	Dynamic hormone study and Magnetic resonance imaging	Patients diagnosed with pituitary stalk lesions
Hyperprolactinemia/prolactinomas	Dynamic hormone study and Magnetic resonance imaging	Patients diagnosed with hyperprolactinemia/prolactinoma
Cushing's disease	Dynamic hormone study and Magnetic resonance imaging	Patients diagnosed with Cushing's disease
Craniopharyngioma	Dynamic hormone study and Magnetic resonance imaging	Patients diagnosed with craniopharyngiomas
Others	Dynamic hormone study and Magnetic resonance imaging	Patients diagnosed with other suprasellar/parasellar lesions

Primary Outcome Measures

Name	Time	Method
Treatment outcome of pituitary diseases	Up to 10 years	Remission rate

Secondary Outcome Measures

Name	Time	Method
Complications of pituitary disease	Up to 10 years	Visual field defect or hypopituitarism, hormone hyperfunction-related complications

Trial Locations

Locations (1)

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of