A feasibility study to suppress myocardial [18F]-FDG uptake by pre-administration of pure caffeine
- Conditions
- cardiac inflammation1002859310003816
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 8
Inclusion Criteria
Recent routine [18F]FDG PET/CT at Erasmus MC with inadequate myocardial
[18F]FDG suppression.
Signed informed consent
Extra-cardiac lesions
Age >= 18 years
Willing to undergo the study procedures
Exclusion Criteria
Pregnancy or breastfeeding
History of heart failure
Uncontrolled or untreated hypertension
Hypersensitivity for caffeine
Use of Methotrexaat, Adenosine, Stiripentol, Melatonin and/or B-blocker
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>To investigate the effect of pure caffeine food supplement on myocardial<br /><br>[18F]FDG uptake suppression and extra-cardiac image quality between the study<br /><br>PET/CT and the routine PET/CT in the same patient.</p><br>
- Secondary Outcome Measures
Name Time Method <p>To monitor the safety and tolerability of pure caffeine food supplement in<br /><br>combination with [18F]FDG.<br /><br>To measure the effect of the additional caffeine on blood glucose and FFA.<br /><br>To gain insight in the physiological uptake pattern uptake due inadequate<br /><br>myocardial suppression.</p><br>