The Effects of Auditory Cueing on Rhythmic Movement and Cortical Excitability in Patients With Parkinson's Disease

Not Applicable

• Conditions: Parkinson's Disease
• Interventions: Procedure: rhythmic auditory stimulation

• Registration Number: NCT02037451
• Lead Sponsor: Chang Gung University

Brief Summary

Parkinson's disease (PD) is a progressive degenerative disease of central nervous systems deficit. The clinical symptoms of Parkinson's disease include the following motor tasks: difficult in initiating movement, performing rhythmic movement or serial movement, the ability of learning motor movement is also affected. The primary treatment for Parkinson's disease is medical treatment; surgery is used if in need. Rehabilitation such as physical therapy, which aims to improve patient's quality of life and functions, is a non-invasive treatment and value for PD patients. Auditory cue is a technique that widely applied on training patients with Parkinson's disease, and some researches revealed that auditory cueing could improve motor performance. However, the mechanism under this treatment technique is still unknown.

This study is to investigate the effect of auditory cueing on rhythmic finger movement in patients with Parkinson's disease. To investigate the mechanism under auditory cueing, neurophysiological data such as motor cortex excitability and blood flow in cortical cortex will be obtained by using Transcranial magnetic stimulation (TMS) and near infrared spectroscopy (NIRS).

Detailed Description

Not available

Study Timeline

• Study Start: 2013-08
• Status Verified: 2014-01
• Study First Submitted: 2014-01-14
• Study First Submitted QC: 2014-01-14
• Last Update Submitted: 2014-01-14
• Study First Posted: 2014-01-16
• Last Update Posted: 2014-01-16
• Primary Completion: 2014-08
• Study Completion: 2014-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 38

Inclusion Criteria

• Clinical diagnosis of Parkinson disease

Exclusion Criteria

• Clinical diagnosis of other neurological diseases
• Dementia
• Been diagnosed with any mental illness
• History of seizures
• Brain trauma
• Body with a pacemaker or other electrical stimulator
• Pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
intervention group	rhythmic auditory stimulation	intervention group which receive auditory cueing while performing movement

Primary Outcome Measures

Name	Time	Method
Motor evoked potential	Baseline,45-60 minute	Use single-pulse TMS to assess Motor evoked potential change.
Finger Tapping	Baseline,45-60 minutes.	Record pre-test and post-test change.
Intracortical inhibition & Intracortical facilitation	Baseline,45-60 minutes	Use paired-pulse TMS to record pre-test and post-test change.
Blood oxygen dependent level	Baseline, in experiment,45-60 minutes	Use Near-infrared spectroscopy to record pre-test, in experiment, and post-test change.

Trial Locations

Locations (1)

Chang Gung University; 🇨🇳 Taoyuan, Taiwan