C-reactive Protein Levels in Acute Apical Abscess Due to Root Canal Infection

Not Applicable

• Conditions: Dentoalveolar Abscess
• Interventions: Procedure: ROOT CANAL TREATMENT

• Registration Number: NCT04684407
• Lead Sponsor: CSI College of Dental Sciences and Research, Madurai

Brief Summary

C-reactive protein levels of patients with acute apical abscess are evaluated before and after root canal treatment

Detailed Description

In patients with acute apical abscess C-reactive proteins are evaluated before and after root canal treatment. In this intra-canal medications calcium hydroxide and triple antibiotic paste are compared. PAI score of the corresponding tooth is noted .

Study Timeline

• Study Start: 2020-11-01
• Status Verified: 2020-12
• Study First Submitted: 2020-12-15
• Study First Submitted QC: 2020-12-22
• Last Update Submitted: 2020-12-22
• Study First Posted: 2020-12-24
• Last Update Posted: 2020-12-24
• Primary Completion: 2022-07-01
• Study Completion: 2022-12-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

patient with acute apical abscess

Exclusion Criteria

• Teeth with evidence of previous initiated root canal treatment
• History of myocardial infarction, coronary heart disease
• Patients allergic to local anesthetic
• Patients under steroid medication
• Patients who are immunocompromised

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Triple antibiotic paste	ROOT CANAL TREATMENT	Triple antibiotic paste (TAP)- combination of metronidazole,ciprofloxacin and minocycline mixed in a ratio of 1:1:1 . TAP paste is combined with propylene glycol and placed as intra canal medication.
calcium hydroxide	ROOT CANAL TREATMENT	calcium hydroxide powder is mixed with normal saline and placed as intra-canal medication

Primary Outcome Measures

Name	Time	Method
Post root canal C reactive protein level	2 weeks	Pre-operative serum c-reactive protein level was measured to which the post operative c-reactive protein level after 2 weeks of root canal treatment are compared.; The normal serum c-reactive protein level is 0 - 6.00 mg/L.

Secondary Outcome Measures

Name	Time	Method
pain and swelling assessment	6 months	pain and swelling reduction after root canal treatment is assessed. . Pain is evaluated using visual analgue scale (VAS) , regarding swellling reduction patient is asked to evaluate subjectively whether the patient profile has returned to normal after the treatment and they were asked how many days it took for the swelling to resolve completely.

Trial Locations

Locations (1)

Csi College of Dental Sciences and Research; 🇮🇳 Madurai, Tamil NADU, India