Identification of objective markers for the evaluation and prediction of the treatment of children and adolescents with ADHD

Recruiting

Conditions: F90.1
F90.0
F98.8
Disturbance of activity and attention
Other specified behavioural and emotional disorders with onset usually occurring in childhood and adolescence
Hyperkinetic conduct disorder

Registration Number: DRKS00030766

Lead Sponsor: niklinik RWTH Aachen Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 150

Inclusion Criteria

Children/adolescents with AD(H)D:
1. AD(H)D diagnosis according to ICD10/DMS-5
2. Children/adolescents aged 8 to 16
3. Written consent
4. Consent of parents/legal guardians
5. Persons who are legally competent and mentally able to follow the instructions of the staff

Healthy controls:
1. Children/adolescents aged 8 to 16
2. Written consent
3. Consent of parents/legal guardians
4. Persons who are legally competent and mentally able to follow the instructions of the staff

Exclusion Criteria

Children/adolescents with AD(H)D:
1. IQ < 80
2. Diagnosed autism spectrum disorder, epilepsy or brain-organic damage
3. Persons who are placed in an institution by order of the authorities or the court
4. Persons who are in a dependent or employment relationship with the researcher

Healthy controls:
1. IQ < 80
2. Diagnosed AD(H)D, autism spectrum disorder, epilepsy or brain-organic damage
3. Persons who are placed in an institution by order of the authorities or the court
4. Persons who are in a dependent or employment relationship with the researcher

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Primary outcome will be response to MPH (8 weeks after completed dosing with MPH)<br><br>Changes in:<br>- Questionnaires (Conner's Rating Scales for parents, child, teachers; Children's Communication Checklist; Medication Adherence Rating Scale; Barkley Scale; Clinical Global Impression Scale; Line Listing)<br>- Neuropsychological assessments (QbTest; Testbattery for attentional performance)<br>- Language- and voice-related assessments (spontaneous speech; verbal fluency test (Regesburger Wortflüssigkeits-Test); phonological working memory (digit span; WISC-V))<br>- Movement and activity data (JTrack)<br>- MRI; <br><br>Follow up interview with parents by phone after three months

Secondary Outcome Measures