IRCT20190519043634N1尚未招募1 期
Intra-testicular Injection of Autologous Adipose Derived Mesenchymal Stem Cell (ADMSC) in Non-obstructive Azoospermia Patients: Clinical Trial, Phase I, Non-Randomized
ational Center of Science and Technology Evaluation0 个研究点目标入组 10 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 10
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 20 years 至 50 years（—）
- 性别
- Male
入选标准
- •20-50 years infertile males seeking fertility treatment with confirmed diagnosis of Non-obstructive azoospermia (NOA).
- •Patients with confirmed diagnostic of Non-obstructive azoospermia based on 2 negative spermogram with centrifugation (three months in between).
- •Patients without sperm cells at semen analysis.
- •Body mass index (BMI) lower than 35.
- •Negative testicular sperm extraction (TESE): Failure of detecting spermatozoid TESE.
排除标准
- •Treated with drug which could improve sperm count and quality one month before observation, otherwise, they should have an elution for 1 month before the study.
- •Previous surgical history in Testis. Absent or surgical removed testes
- •Infectious genital diseases. Gram-positive bacteria, Chlamydia Trachomatis,Ureaplasma Urealyticum, or Mycoplasma Hominis were detected in their semen.
- •Anatomical abnormalities of the genital tract
- •Patients with grade 2 or 3 varicocele, persistent after cure of the varicocele.
- •Current or history of testicular tumor detected or testicular cancer or history of any other cancer.
- •Obstructive azoospermia (FSH <7.6 IU/mL plus testicle longitudinally axis >4.6 cm or bilateral absence of vas deferens or surgical history of vasectomy).
- •Hypogonadotropic hypogonadism (LH <2 IU/mL and Follicle Stimulating Hormone (FSH) <1 IU/mL).
- •Patient with Klinefelter or karyotype abnormalities
- •Seminal white blood cell concentration more than 10 million per ml
- •Use of chemotherapy, testosterone, or anti-androgen in the last two years.
- •Partner >40 years or female factor infertility associated.
- •Addicted to drug, tobacco, or alcohol.
- •Under treatment of gonadotropin, anabolic steroid, chemotherapeutic drugs, or nonsteroidal anti-inflammatory drugs.
- •Combined with cardiovascular, liver, kidney, or hematopoietic system severe primary disease, or mental disease.
- •Had heat, chemicals, radioactive material, or toxic contact history within a year.
- •Presence of genetic disorders: abnormal karyotypes and Chromosomal aberration (e.g. Y microdeletion, trisomy….
- •First TESE conducted under hormonal treatment (Clomifene, Tamoxifen, gonadotrophins or anti-aromatase)
- •Receiving a treatment known to alter male fertility (see RCP of the treatment, colchicine, methotrexate and…) in the 6 months before inclusion.
- •Receiving treatment know to modify the gonadotroph axis activity (FSH, TESTO, DHT, HCG…)
- •Persistent bilateral abdominal cryptorchidism or history of cryptorchidism
- •Patient unable to understand the purpose of the trial or refusing to follow treatment and post-treatment instructions
- •Participation to another trial that would interfere with this trial
研究者
相似试验
已完成
不适用
Periurethral injection of autologous adipose-derived stem cells from liposuction for the treatment of stress urinary incontinencestress urinary incontinenceJPRN-UMIN000006116Department of Urology, Nagoya University Graduate School of Medicine30
已完成
Unknown
Single intracavernous injection of autologous adipose-derived stem cells versus a single high dose of Platelet Rich Plasma to improve erectile dysfunction: A comparative studyErectile dysfunctionJPRN-UMIN000049397Al Zahraa Hospital20
招募中
1 期
SUBCUTANEOUS INJECTIONS OF AUTOLOGOUS CULTURED ADIPOSE-DERIVED STROMA/ STEM CELLS TO HEAL REFRACTORY ISCHEMIC DIGITAL ULCERS IN PATIENTS WITH SCLERODERMASystemic sclerosisCTIS2023-508432-53-00Centre Hospitalier Universitaire De Toulouse32
进行中（未招募）
1 期
Adipose tissu derived-stem cells injections from patients with sclerodermia to treat thier refractory digital ulcers.Patients with systemic sclerosis presenting digital ulcer :- located beyond the proximal interphalangeal joint, on finger surface (included periungueal ulcers),- of ischemic origin according to the physician,- not over subcutaneous calcifications or bone relief,- active DU- refractory after 10±2 weeks of standard of care (that is either still active or new occurrence despite standard of care)EUCTR2019-003906-28-FRCHU de Toulouse32
尚未招募
不适用
Intra-articular injection of adipose-derived stromal vascular fraction in osteoarthritis of the temporomandibular jointNL-OMON24620MCG40