Intravenous Lidocaine Reduces Pain Scores and Opioid Consumption in Open Lung Resection Surgery: A Prospective Randomized Double-Blind Controlled Trial
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Pain scores at rest and at cough
研究概览
简要总结
Management of postoperative pain in 2020 remains a challenge for anesthesiologists in the perioperative period. Lidocaine is an amide local anesthetic, it is one of the oldest adjuvant analgesics and is known to possess analgesic, anti-hyperalgesic and anti-inflammatory properties. Lidocaine is proven to be as effective as epidural analgesia in colorectal surgery.
However, no study has evaluated the effect of a continuous lidocaine infusion for open lung resection in the post-operative period. The present study aims to evaluate the influence of IV lidocaine given during and 24 hours after surgery, on pain scores, opioid consumption, and possible benefits on patient outcome via the opioid-sparing effect in open thoracic surgery
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American society of anesthesiologists (ASA) scores of I, II or III.
- •Left or right posterolateral thoracotomy with postoperative monitoring in the intensive care unit (ICU) for at least 24 hours (h).
排除标准
- •patient's refusal to participate
- •ASA score of IV or higher
- •severe hepatic or renal insufficiency
- •allergy to lidocaine, morphine or NSAIDs
- •cardiac arrhythmias or
- •epilepsy,
- •delayed extubation for more than 2 h postoperatively
- •urgent surgery
研究组 & 干预措施
Placebo Group
Equal bolus volume of normal saline solution at induction, and then a continuous infusion started before surgical incision and maintained up until 24h postoperatively
干预措施: Normal Saline (Drug)
Lidocaine Group
Bolus of lidocaine 1% 1.5mg/kg at the induction of general anesthesia followed by a continuous infusion of lidocaine 1% 2mg/kg/h just before surgical incision and continued until 24h after the surgery
干预措施: Lidocaine Iv (Drug)
结局指标
主要结局
Pain scores at rest and at cough
时间窗: Measurements were made for 24 hours in the post operative period
Analogue visual scale ( a 10cm scale , zero representing no pain and 10 representing the worst imaginable pain)) was used to measure pain scores for each patient at rest and at cough
Opioid consumption in the post operative period
时间窗: Doses were measured for twenty four hours in the post operative period
Total dose of morphine in the post operative period is measured for patients in both arms
次要结局
- Pulmonary complications(Measurements were recorded for 24 hours in the post operative period)
研究者
Afrida Gergess
Anesthesiologist specialized in cardiovascular and thoracic surgery
Saint-Joseph University