Role of Left Bundle Branch (LBB) pacing in heart failure - An Observational Study

Not Applicable

• Conditions: Heart Failure; Prolonged QRSduration (QRSd) >150 ms; Left Bundle Branch Block (LBBB); Right Bundle Branch Block (RBBB); Cardiovascular - Other cardiovascular diseases

• Registration Number: ACTRN12623000088640
• Lead Sponsor: DR. RAJEEV PATHAK

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-01-25
• Last Update Posted: 30 January 2023

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

Severe LV systolic dysfunction despite optimal medical management and indication for Permanent Pacemaker/CRT
Prolonged QRSd >150MS
Left Bundle Branch Block (LBBB) or
Right Bundle Branch Block (RBBB) or
Inter-Ventricular Conduction Delay (IVCD)
Symptoms - NYHA Class II AND III
Where tradition Biventricular pacing or LBB pacing is possible, i.e absence of complex congenital heart disease

Exclusion Criteria

Those with limited life expectancy due to comorbidity
Advanced cancer
Refuse to/unable to give consent
Complex congenital heart disease where lead placement is not possible
Pregnancy
When heart failure or prolonged QRS are assumed to be transient and expected to recover

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
eft Ventricular Ejection Fraction by echocardiography<br>[6 months, 12 months, 24 months post CRT];QRSd by 12 lead ECG[6 months, 12 months, 24 months post CRT]

Secondary Outcome Measures

Name	Time	Method
Symptoms - New York Heart Association (NYHA) class[6 months, 12 months, 24 months post CRT];Quality of Life by SF36 questionnaire - Patient reported survey of patient health[6 months, 12 months, 24 months post CRT];LV end diastolic volume by echocardiography[6 months, 12 months, 24 months post CRT];LV end systolic volume by echocardiography[6 months, 12 months, 24 months post CRT]