Studie naar het effect van ursodeoxycholzuur (ursochol) en ezetimibe op de uitscheiding van vetten in de ontlasting en op de concentratie van vetten in het bloed
Completed
- Conditions
- Hypercholesterolemia, fecal cholesterol excretion, ABCG5/8, NPC1L1, trans-intestinal cholesterol excretion
- Registration Number
- NL-OMON19907
- Lead Sponsor
- Academisch Medisch Centrum (AMC), Amsterdam
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
Hypercholesterolemia, with LDL plasma levels >2.6 mmol/L
- Body mass index (BMI) ¡Ý19 ¡Ü30 kg/m2
Exclusion Criteria
- Medical, surgical, laboratory or other conditions, which in the judgment of the Physician Investigator would make the subject unsuitable for enrollment, or potentially interfere with subject participation or completion of the study
- Suffering from an inflammatory bowel disease, e.g. Crohn¡¯s disease or ulcerative colitis.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Total faecal sterol concentration (faecal total neutral sterol concentration (FNS) + faecal bile acid concentration)
- Secondary Outcome Measures
Name Time Method ipid profile/composition: LDL-c, HDL-c, TG, apoB, apoA1.