Impaired Regulation of Energy Balance in Elderly People (Balance Study)

Not Applicable

Completed

• Conditions: Anorexia of Ageing
• Interventions: Other: Energy restriction period

• Registration Number: NCT00561145
• Lead Sponsor: Wageningen University

Brief Summary

Over the past century life expectancy has risen rapidly. As a result, the proportion of elderly people continues to grow. Elderly people probably have an impaired regulation of energy balance (energy intake versus energy expenditure) whereby the underlying physiological mechanisms are not fully understood.

The first objective of this study is to provide further evidence for an age-related failure to regulate energy balance in elderly. If the hypothesis of impaired regulation of energy balance in elderly is confirmed then the second objective becomes to elucidate the underlying physiological mechanisms of the age-related failure to regulate energy intake in elderly.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-10
• Study First Submitted: 2007-11-19
• Study First Submitted QC: 2007-11-19
• Study First Posted: 2007-11-20
• Primary Completion: 2010-03
• Study Completion: 2012-03
• Results First Submitted: 2012-03-20
• Status Verified: 2016-02
• Results First Submitted QC: 2016-02-12
• Last Update Submitted: 2016-02-12
• Results First Posted: 2016-03-11
• Last Update Posted: 2016-03-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 32

Inclusion Criteria

• men
• healthy
• 20-40 and 65-85 years of age
• normal weight
• free-living in Wageningen and surrounding

Exclusion Criteria

• anemia
• diabetes
• restrained eating
• dementia
• weight changes of > 2 kg during the last 2 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Young men	Energy restriction period	Energy restriction period
Elderly men	Energy restriction period	Energy restriction period

Primary Outcome Measures

Name	Time	Method
Energy Intake Compensation	Average intake of energy during ad lib phase (9 days)	To assess energy intake compensation, we will assess average energy intake during the ad libitum food intake phase - which is the period after energy restriction- in young men and compare this to average energy intake in older men.; Average energy intake is assessed by measuring total megajoule of energy intake during nine days of the ad lib phase, and then divide it by nine (MJ/day)

Secondary Outcome Measures

Name	Time	Method
Gastrointestinal Function	Before and after the energy restriction period
Appetite/Satiety Hormones and Questionnaires	Before and after the energy restriction period.
Resting Energy Expenditure, Body Composition and Body Weight	Before and after the energy restriction period
Expression of Genes Involved in Energy Metabolism	Before and after the energy restriction period.

Trial Locations

Locations (1)

Wageningen University, Division of Human Nutrition; 🇳🇱 Wageningen, Gelderland, Netherlands