Impaired Regulation of Energy Balance in Elderly People and the Underlying Physiological Mechanisms.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 32
- 试验地点
- 2
- 主要终点
- Energy Intake Compensation
研究概览
简要总结
Over the past century life expectancy has risen rapidly. As a result, the proportion of elderly people continues to grow. Elderly people probably have an impaired regulation of energy balance (energy intake versus energy expenditure) whereby the underlying physiological mechanisms are not fully understood.
The first objective of this study is to provide further evidence for an age-related failure to regulate energy balance in elderly. If the hypothesis of impaired regulation of energy balance in elderly is confirmed then the second objective becomes to elucidate the underlying physiological mechanisms of the age-related failure to regulate energy intake in elderly.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 85 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •20-40 and 65-85 years of age
- •normal weight
- •free-living in Wageningen and surrounding
排除标准
- •restrained eating
- •weight changes of > 2 kg during the last 2 months
结局指标
主要结局
Energy Intake Compensation
时间窗: Average intake of energy during ad lib phase (9 days)
To assess energy intake compensation, we will assess average energy intake during the ad libitum food intake phase - which is the period after energy restriction- in young men and compare this to average energy intake in older men. Average energy intake is assessed by measuring total megajoule of energy intake during nine days of the ad lib phase, and then divide it by nine (MJ/day)
次要结局
- Appetite/Satiety Hormones and Questionnaires(Before and after the energy restriction period.)
- Gastrointestinal Function(Before and after the energy restriction period)
- Resting Energy Expenditure, Body Composition and Body Weight(Before and after the energy restriction period)
- Expression of Genes Involved in Energy Metabolism(Before and after the energy restriction period.)
研究者
Lisette de Groot
Professor
Wageningen University