Characterization of decision-making and action adaptation in obsessive-compulsive disorder and its modulation through deep brain stimulatio

Not Applicable

Recruiting

• Conditions: F42; Obsessive-compulsive disorder

• Registration Number: DRKS00014670
• Lead Sponsor: niversitätsklinikum Köln

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-04-27
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 55

Inclusion Criteria

Patient approves to be evaluated
- Patients have to be capable to give consent
- Written informed consent

Exclusion Criteria

- clinical relevant psychiatric disorder
- severe and instable physical disorder and brain tumors
- clinical relevent internal or neurological disorder
- pregnancy or breast feeding
- suicidal tendencies or violent behavior in the last 4 weeks
- acute psychotic symptoms
- current sedative medication with benzodiazepines
- hospitalization according to PsychKG

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
We observe cognitive flexibility especially action adaptation using a Task switching paradigm. A switch between cognitive tasks is associated with switching-costs. Higher switching-costs are designated by prolonged reaction times and are an indicator for decreased cognitive flexibility.<br><br>We plan a comparison of the switching-costs and the associated electrophysiological potentials (P3) between patients with OCD, DBS-patients with OCD (acute effect of the on/off condition), and healthy controls.<br>

Secondary Outcome Measures

Name	Time	Method
Parameters of the patch-leaving task. We plan a comparison between patients with OCD, DBS-patients with OCD (acute effect of the on/off condition), and healthy controls, including the associated electrophysiological potentials.