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Clinical Trials/NCT03629509
NCT03629509
Unknown
Not Applicable

Implementation of the Begin Exploring Fertility Options, Risks and Expectations (BEFORE) Decision Aid - A Stepped Wedge Cluster Randomized Trial

Unity Health Toronto1 site in 1 country224 target enrollmentSeptember 1, 2018

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Decision Support Techniques
Sponsor
Unity Health Toronto
Enrollment
224
Locations
1
Primary Endpoint
Patient-reported outcome questionnaire - Fertility Preservation Questionnaire
Last Updated
7 years ago

Overview

Brief Summary

Fertility is of great importance to young women with cancer. Concerns about the ability to become pregnant after cancer treatment may influence treatment decisions and fertility decision-making is challenging. Despite these challenges, there is a lack of fertility decision support tools. Our team developed the Begin Exploring Fertility Options, Risks and Expectations (BEFORE) decision aid for young breast cancer patients in Canada. This study aims to evaluate the implementation of the BEFORE decision aid in hospital settings through a stepped wedge cluster randomized trial.

Detailed Description

The investigators will conduct a stepped wedge cluster randomized trial to sequentially implement the BEFORE decision aid in clinical settings that are currently recruiting young breast cancer patients for the Reducing the bUrden of Breast cancer in Young women (RUBY) Study (www.womensresearch.ca/ruby-study/). For this trial 24 participating RUBY sites were grouped into 14 clusters (1 to 3 sites per cluster). The decision aid intervention will be sequentially rolled out over the course of 48 weeks to all clusters. None of the clusters will be switched from control to intervention during the first 6 weeks of the study to establish a baseline. Then two clusters will move from the control to the intervention every 6 weeks (called a 'step'). There will be 7 steps total during the study period. At the end of the 7th step all clusters (i.e., participating RUBY sites) will have received the decision aid intervention. The time-point of when the clusters will be switched from control to intervention will be randomized. The data collection includes obtaining secondary data collected as part of the RUBY study from all patient participants who were enrolled in RUBY during the study period. The primary outcome is the number of patients reporting that fertility tools were recommended to them, based on RUBY participant responses to a 3-month fertility questionnaire. The investigators hypothesizes that following the implementation of the decision aid intervention a 20% difference will be observed, from 10% in the control to 30% in the intervention, in the number of patients who report that someone in their care team recommended a fertility tool.

Registry
clinicaltrials.gov
Start Date
September 1, 2018
End Date
December 31, 2019
Last Updated
7 years ago
Study Type
Interventional
Study Design
Crossover
Sex
Female

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Nancy Baxter

Chief of General Surgery, Scientist

Unity Health Toronto

Eligibility Criteria

Inclusion Criteria

  • Young females diagnosed with histologically-confirmed breast cancer will be eligible to participate if they:
  • are age =18 years and prior to their 41st birthday;
  • are able to provide verbal informed consent and complete the interviews in English or French;
  • completed the 3-month fertility questionnaire as part of the RUBY Study.

Exclusion Criteria

  • Not provided

Outcomes

Primary Outcomes

Patient-reported outcome questionnaire - Fertility Preservation Questionnaire

Time Frame: 3 months from date of randomization

Number of patients reporting that fertility tools were recommended to them following their breast cancer diagnosis

Secondary Outcomes

  • BEFORE decision aid online survey - Provider Recommendation of Decision Aid(From date of randomization until the end of the study at 48 weeks)
  • BEFORE decision aid online survey - Patient Learning About Decision Aid(From date of randomization until the end of the study at 48 weeks)
  • BEFORE decision aid online survey - Patient Satisfaction(From date of randomization until the end of the study at 48 weeks)

Study Sites (1)

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