se of tooth derived (Dentin) bone graft with platelet derived growth factor for the regeneration of bone loss due to periodontitis.

Not Applicable

Completed

• Conditions: Health Condition 1: K053- Chronic periodontitis

• Registration Number: CTRI/2022/06/043426
• Lead Sponsor: Indian Council of Medical Research

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2024-02-16
• Last Update Posted: 22 July 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 29

Inclusion Criteria

1. Teeth without root canal fillings that are extracted due to advanced periodontal bone loss or fractures which have a hopeless prognosis.

2. Patient with moderate to severe chronic periodontitis with no other systemic disease.

3. Presence of deep infra-bony defect with a probing depth of >5 mm at baseline.

4. Presence of infra-bony component of at least 3 mm as detected on the radiograph.

5. Patients with a good level of oral hygiene with Plaque Index (PI, Loe and Sillness).

Exclusion Criteria

1. Root canal treated teeth

2. Patients with systemic disease discovered on routine investigations during the study

(such as diabetes mellitus, hypertension, etc.) which could influence the outcome of the

study.

3. Pregnant and lactating mothers or those planning a pregnancy.

4. History within the last 6 months of oral cancer or human immunodeficiency virus (HIV).

5. Patients with life threatening disease

6. History of previous periodontal surgery on the study tooth within the last year;

7. Patients with bleeding disorders.

8. Patients suffering from allergic conditions or a history of allergies.

9. Patients on long-term antibiotics.

10. the study tooth exhibiting a Class 3 furcation defect

11. clinical or radiographic signs of untreated acute infection at the surgical site, apical

pathology, root fracture, severe root irregularities, cemental pearls; cementoenamel

projections not easily removed by odontoplasty, untreated carious lesions at the

cementoenamel junction (CEJ) or on the root surface, subgingival restorations, and/or

restorations with open margins at or below the CEJ

12. History within the last 6 months of weekly or more frequent use of smokeless chewing

tobacco, pipe or cigar smoking or smoking more than 20 cigarettes per day

13. Allergy to yeast-derived products;

Study & Design

• Study Type: Interventional
• Study Design: Not specified