Search for BIO Diagnostic and Prognostic Markers in Adult VAScularitis
- Conditions
- Vasculitis
- Interventions
- Other: Sampling
- Registration Number
- NCT05565885
- Lead Sponsor
- University Hospital, Tours
- Brief Summary
To date, there are no reliable diagnostic blood markers of adult vasculitis. To date, the diagnosis of vasculitis is based on invasive procedure, biopsy of affected tissues potentially at risk of complication . In addition, there are no reliable biomarkers to predict the evolution of vasculitis (relapse, refractory form ...) necessary for the management of patients (type of treatment, duration ..)
Prospective study, monocentric (CHU de Tours), non-interventional, aimed at finding diagnostic and prognostic biomarkers (both metabolomic and immunologic) in adult vasculitis patients.
- Detailed Description
Specimen will be collected at diagnosis, month 1, month 3, and month12 and at the time of a possible relapse. 14 ml of additional blood during a blood puncture made for routine care will be collected at each visit as well as clinical data.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 225
- Age > 16 years
- Active vasculitis, new diagnosis or relapse
- IgA vasculitis
- ANCA vasculitis
- Giant cell arteritis
- Person who has objected to the processing of data
- Pregnant woman
- Patient positive for HIV, HBV, HCV
- Treatment in the previous month with corticosteroids, immunosuppressive drugs or biotherapy.
- Patient unable to understand the information leaflet
- Adult under guardianship or curatorship
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description patients with vascularitis Sampling Two additional 7ml EDTA tubes of blood are taken from the same blood puncture as during routine follow-up at several points in the follow-up
- Primary Outcome Measures
Name Time Method cytokine/chemokine/metabolite concentrations date of relapse assessed up to 12 months Analysis by méthod Luminex
percentage of different non-conventional T cell populations date of relapse assessed up to 12 months study by flow cytometry
- Secondary Outcome Measures
Name Time Method cytokine/chemokine/metabolite concentrations date of relapse assessed up to 12 months identify a metabolomic blood profile for the prognosis of vasculitis
percentage of different non-conventional T cell populations date of relapse assessed up to 12 months identify an immunological blood profile for the prognosis of vasculitis
metabolomic pathway date of relapse assessed up to 12 months Identify a metabolomic pathway involved in the pathophysiology of vasculitis that could be a target for therapy.
immunological pathway date of relapse assessed up to 12 months Identify an immunological pathway involved in the pathophysiology of vasculitis that could be a target for therapy.
Trial Locations
- Locations (1)
University hospital
🇫🇷Tours, France