Genetic of Aortic Valve Stenosis - Clinical and Therapeutic Implications
- Conditions
- Aortic Valve Stenosis
- Registration Number
- NCT00647088
- Lead Sponsor
- Assistance Publique - H么pitaux de Paris
- Brief Summary
Pathophysiology of Aortic Valve Stenosis remains poorly known. The aim of the present study is to identify genetic factors involved in this disease using a case control trial design.
- Detailed Description
Aortic valve stenosis (AS) is the most common valvular disease and the second most common indication for cardiac surgery in Western countries. AS has long been considered as a passive and degenerative process. Recent data challenged this concept, showing that AS is an active and highly regulated process with some similarities to atherosclerosis. However, pathophysiology of AS remains poorly understood and preliminary data suggest that genetic factors may be involved. The aim of the present study is to identify genetic factors involved in this disease using a case control trial design (1000 patients with AS and 1500 controls with no evidence of valve disease). For all patients and controls, blood samples including DNA and echocardiography will be performed.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 2200
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Identification of genetic polymorphisms of fetuin-A, matrix-GLA protein, vitamin D receptor end of the study
- Secondary Outcome Measures
Name Time Method Identification of other genetic polymorphisms End of the Study
Trial Locations
- Locations (1)
Assistance Publique - H么pitaux de Paris, Bichat Hospital
馃嚝馃嚪Paris, France