The Effects of Trout Fed With a Vegetable Based Feed on Cardiovascular Risk Markers and Plasma Proteome

Not Applicable

Completed

• Conditions: Cardiovascular Disease
• Interventions: Behavioral: Effects of trout on CVD risk markers and plasma proteome

• Registration Number: NCT00445614
• Lead Sponsor: University of Copenhagen

Brief Summary

Fish from the aquaculture sector constitutes an increasing part of the fish consumption in Denmark. The most important farmed fish in Denmark is the rainbow trout. Due to limited access of wild fish for the feed production, alternative feeding regimes of vegetable origin such as vegetable proteins and rapeseed oil are used instead of marine feed. This change in feeding regime may affect flesh quality and health and nutritional properties as the content of long-chain n-3 polyunsaturated fatty acids (n-3 LCPUFA) will presumably decrease in the meat. The objective of the study is to investigate the effect of vegetable based feed versus marine feed of farmed trout and its effect in healthy men on cardiovascular risk markers associated with the development of cardiovascular disease (CVD).

Detailed Description

In a two month parallel study including 60 healthy men aged 40-70 years, the cardiovascular effect of one daily meal of trout fed with a vegetable based feed are compared with that of trout fed with marine feed (estimated intake of n-3 LCPUFA 2.6 g/day) and a standard Danish diet with poultry. Men are randomised to one of the three groups. Red blood cell fatty acid composition, classical cardiovascular disease (CVD)-risk markers (blood pressure and plasma lipid profile), newer CVD-markers (arterial compliance and plasma markers of endothelial function and inflammation) and plasma proteome analysis are measured at the beginning and end of the intervention period.

Study Timeline

• Study Start: 2007-03
• Study First Submitted: 2007-03-08
• Study First Submitted QC: 2007-03-08
• Study First Posted: 2007-03-09
• Primary Completion: 2007-12
• Study Completion: 2007-12
• Status Verified: 2008-08
• Last Update Submitted: 2008-08-12
• Last Update Posted: 2008-08-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 72

Inclusion Criteria

• Age 40-70
• Body mass index 18,5 - 30

Exclusion Criteria

• Exercise >10 h/week
• Chronical diseases (eg. cardiovascular and diabetes)
• Regular medication
• Fish oil supplementation
• Blood donation 2 month prior or during participation
• Above maximum recommended alcohol intake
• Blood pressure >160/100 mm Hg

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Marine trout	Effects of trout on CVD risk markers and plasma proteome	150 g/day of trout fed on marine based feed
Vegetable trout	Effects of trout on CVD risk markers and plasma proteome	150 g/d of trout fed on vegetable based feed
Poultry	Effects of trout on CVD risk markers and plasma proteome	150 g/d of poultry (for comparison)

Primary Outcome Measures

Name	Time	Method
pulse wave analysis
pulse wave velocity
cardiovascular risk markers
blood pressure
plasma protein expression
markers of inflammation
plasma lipids

Trial Locations

Locations (1)

Department of Human Nutrition, Denmark; 🇩🇰 Frederiksberg, Denmark