NCT03017976Unknown不适用
Swan Study: Swimming Pool Environment Impact on the Human Respiratory Health
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Spirometry with bronchodilation
研究概览
简要总结
This study aims to assess the influence of exposure to swimming pool environment on respiratory symptoms and diseases, and on cancer outcomes among swimmers and swimming pool attendants.
详细描述
Objectives:
- In relation to human exposure 1.1. To assess the levels of certain disinfection by-products (DBPs) in blood and urine (biomarkers of exposure); 1.2. To assess swimming induced changes in biomarkers of genotoxicity, specifically micronuclei (MN) in exfoliated urothelial cells and buccal cells and DNA damage in peripheral blood lymphocytes, urine mutagenicity and in exfoliated urothelial; 1.3. To assess the effects of swimming pool exposure on oxidative stress and lung damage in swimming pool users; 1.4. To assess the impact of DBPs, including volatile DBPs on airway function, inflammation and reactivity; 1.5. To assess the impact of swimming on skin transepidermal water loss and dermal condition.
- In relation to swimming pool environment 2.1. To assess water and air quality through the analysis of several chemical (DBPs and other), physicochemical and microbiological parameters and the associated short-term variation of their levels (hourly and daily); 2.2. To assess microbiological contamination of highly used surfaces; 2.3. To assess mutagenicity of indoor chlorinated and brominated swimming pool water.
Methods
Study setting Chlorinated and brominated public indoor municipal swimming pools in the North of Portugal.
Study design
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 12 Years 至 —(Child, Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Spirometry with bronchodilation
时间窗: First week after recruitment
Volatile organic compounds in the exhaled breath condensate
时间窗: First week after recruitment
Airway resistance measurement
时间窗: First week after recruitment
Airway reactance measurement
时间窗: First week after recruitment
Fractional concentration of orally exhaled nitric oxide
时间窗: First week after recruitment
次要结局
- Diagnosis of immunoglobulin E (IgE) mediated allergies by skin prick testing(First week after recruitment)
- Autonomic nervous system function assessment by pupillometry(First week after recruitment)
- Transepidermal water loss(First week after recruitment)
研究者
研究点 (1)
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