Imaging Lens Deposits in Exfoliation Syndrome

Terminated

• Conditions: Cataracts; Exfoliation Syndrome; Primary Open Angle Glaucoma
• Interventions: Device: anterior segment OCT

• Registration Number: NCT02042703
• Lead Sponsor: Duke University

Brief Summary

The purpose of this study is to use a special eye imaging technique, anterior segment optical coherence tomography (AS-OCT), to image the lens (the curved, transparent part of the eye that helps you to see clearly by directing images of light onto the back of your eye) and note any changes in exfoliation syndrome. Exfoliation syndrome is a common condition that has many ways of showing up in the eye, including the formation of deposits in the eye, shakiness of the lens that can complicate cataract surgery, and a higher chance of developing a type of glaucoma called exfoliation glaucoma. In this study we plan to collect images and measure exfoliation deposits on the lens with AS-OCT, which can take high resolution pictures of the eye without requiring contact with the eye. We will compare lens images of subjects with exfoliation syndrome to those of subjects with primary open angle glaucoma and cataracts. This type of imaging could be used in patients with known diagnosis of exfoliation syndrome to track disease progression and see how they respond to possible treatments. We also hope that with this imaging technology we can detect early changes in currently unaffected eyes, which could be useful for predicting which patients may develop the disease.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2014-01-21
• Study First Submitted QC: 2014-01-21
• Study First Posted: 2014-01-23
• Study Start: 2014-02
• Primary Completion: 2015-09
• Study Completion: 2015-09
• Status Verified: 2015-10
• Last Update Submitted: 2015-10-20
• Last Update Posted: 2015-10-21

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 4

Inclusion Criteria

• Diagnosis of exfoliation syndrome, primary open angle glaucoma (POAG), or cataracts

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Exclusion Criteria

• Unable to provide or sign consent
• Pseudophakia
• Other prior intraocular surgery
• Other eye diseases other than refractive error

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
cataracts	anterior segment OCT	patients with cataracts
POAG	anterior segment OCT	patients with primary open angle glaucoma (POAG)
exfoliation syndrome	anterior segment OCT	patients with exfoliation syndrome

Primary Outcome Measures

Name	Time	Method
Amount of exfoliation deposits on the lens as measured by AS-OCT	20 min (length of imaging)

Trial Locations

Locations (1)

Duke University Medical Center; 🇺🇸 Durham, North Carolina, United States