Cultured keratinocytes in burn wound care
- Conditions
- Severe burns - acuteInjury, Occupational Diseases, PoisoningBurn and corrosion, body region unspecified
- Registration Number
- ISRCTN63305738
- Lead Sponsor
- Queen Mary University London (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 10
1. Patients who are 18 years old at least
2. Patient is in good general health
3. Patient is willing and able to co-operate with the protocol for the duration of the study
4. Patients with a donor graft site due to requiring a split skin graft to treat a large burn
5. Patients able to give written consent
1. Patients unable to give written consent
2. Terminally ill patients
3. Pregnant women
4. Patients with skin disorders that may affect the growth of cells or subsequent wound healing e.g. patients on high concentrations of steroids, patients with psoriasis or eczema
6. Patient has a history of hypersensitivity to any components of either Cryoskin Spray (e.g. DMSO) or ReCell (trypsin)
7. Patients with eczema; genetic skin conditions; hypertrophic or keloid scars
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Objective measures of wound healing via punch biopsy analysis (time course of cytokine and growth factor expression)
- Secondary Outcome Measures
Name Time Method 1. Time to complete wound closure (100% re-epithelialisation)<br>2. Aesthetic outcome of burn site via Derriford Appearance Scale and Patient and Observer Scar Assessment Scale (POSAS) at week 4, 8, 12 and 24