Understanding Cancer in the Elderly: A combined Retrospective and Prospective Analysis from the Geriatric Oncology Clinic at AIIMS, New Delhi
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 2,000
- 试验地点
- 1
- 主要终点
- geriatric vulnerabilities
研究概览
简要总结
Indian population is aging with increased percentage of older age population. This further increases the prevalence of chronic, non-communicable diseases, of which malignancies are one. Two important aims of treatment in older patients with cancer are increasing survival and improving their health-related quality of life (HRQoL). The management of older cancer population is challenging in view of increased number of comorbidities and increased age-related issues, which can be assessed by comprehensive geriatric assessment. Some fit older patients are denied active intervention, despite their tumor being amenable to radical treatment, because of fear of excessive morbidity (6) and sometimes even frail older patients undergo aggressive therapy leading to toxicity, morbidity and mortality (7). Striking right balance is the key, but it is challenging. Geriatric medicine department in AIIMS has a high flow of patients, and most of the patients are diagnosed with malignancies during evaluation, and sending them to medical oncology department leads to loss to follow up from geriatric department and sometimes break in line of care. Hence, geriatric oncology clinic has been started in National Centre of Ageing, in collaboration with medical oncology team from IRCH. The main aim of geriatric oncology clinic is to provide comprehensive care under one roof and improve the outcome of the patients
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 65.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •All treatment naïve patients with diagnosis of malignancy
- •ECOG performance status 0 to 3.
排除标准
- •Patients requiring radiotherapy intervention
- •Patients/ caregivers refuse for geriatric assessment
- •Patients refuse to give written informed consent
- •Patients having major neurological or medical disorder that impairs their ability to understand the study and give written informed consent.
结局指标
主要结局
geriatric vulnerabilities
时间窗: at 3 months, 6 months and 1 year
次要结局
- quality of life of patients(at baseline, 3 months and 6 months)
- Chemotherapy toxicity risk assessment(3 and 6 months)
- caregiver burden(at baseline)
- non-cancer life expectancy(baseline)
- oncology related parameters: types of malignancy, staging, treatment planned(at baseline)
- treatment abandonment, lost to follow up, overall survival, and disease-free survival in these patients(3 months, 6 months and 1 year)
- correlation of different geriatric conditions, clinical parameters, laboratory parameters with different outcomes (chemotherapy toxicity, overall survival, and quality of life) of the patients(3, 6 and 12 months)
- impact of different individualized interventions (geriatric-assessment based, change in medical management) on different outcomes (chemotherapy toxicity, overall survival, and quality of life, patients and caregiver satisfaction)(3,6 and 12 months)
研究者
Dr NIDHI SONI
AIIMS, New Delhi India