A study to determine the best use of salbutamol in children with acute severe asthma
- Conditions
- The mainstay of asthma treatment worldwide are ß2-agonists and steroids. Current management of childhood acute asthma is based on British Thoracic Society guidelines, which recommend IVS as second line treatment. Whilst IVS can be highly effective in reversing bronchospasm, the overall evidence for this recommendation is week and predominantly comes from a single study. IVS has also been associated with side effects such as arrhythmias, lactic acidosis and diastolic hypotension.Therapeutic area: Diseases [C] - Respiratory Tract Diseases [C08]
- Registration Number
- EUCTR2014-002996-27-GB
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- 54
1. Patients aged 1-15 years (inclusive) with acute severe asthma as defined by the BTS guidelines are eligible
2. About to receive / receiving IVS
3. ED cohort: Patients being admitted for acute asthma treatment in the Royal London Hospital or St Mary’s Hospital EDs while the research nurse is in attendance
4. CATS cohort: Patients being retrieved by the CATS team to Great Ormond Street Hospital or St Mary’s Hospital PICU over the study period.
Are the trial subjects under 18? yes
Number of subjects for this age range: 0
F.1.2 Adults (18-64 years) no
F.1.2.1 Number of subjects for this age range 0
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range 0
Patients being admitted to hospital for a primary reason other than asthma management will be excluded from the study.
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method