A Randomized Double Blind Trial Comparing the Effect of Transversus Abdominal Plane-catheter and Epidural Catheter on Postoperative Pain After Open Gynecologic Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Bupivacain-infusion in epidural catheter
- Conditions
- Pain, Postoperative
- Sponsor
- Aalborg University Hospital
- Locations
- 1
- Primary Endpoint
- Pain-score on numerical rating scale
- Status
- Withdrawn
- Last Updated
- 10 years ago
Overview
Brief Summary
This study compares the effect on postoperative pain of bolus administration of ropivacaine in Transversus abdominis plane catheter and continuous bupivacain-infusion in epidural catheters following open gynecologic surgery.The study is double blind. The hypothesis is that the effect of the two modes of pain treatment are equal.
Detailed Description
Patients for open gynecologic surgery will all receive both an epidural catheter and bilateral transversus abdominis plane (:TAP) catheters. After randomization in to two groups the patients receive either 1) intermittent boluses of ropivacaine in the TAP-catheters and isotonic potassium chloride-infusion i the epidural catheters or 2) intermittent isotonic potassium chloride-boluses i the TAP-catheters and bupivacain-infusion in the epidural catheters. The investigators record pain-score and consumption of opioids in the first 24 hours postoperatively as well as thermoanalgesia at dermatome-levels th10-th12. The investigators assume that the effect on postoperative pain after open gynecologic surgery is equal in the two groups.
Investigators
Nils Bjerregaard
Consultant Anesthetist
Aalborg University Hospital
Eligibility Criteria
Inclusion Criteria
- •patients scheduled for open gynecologic surgery
- •acceptance to participate
Exclusion Criteria
- •allergies to local analgetics
- •daily use of strong opioids
Arms & Interventions
Bupivacain-infusion in epidural catheter
Bupivacain-infusion in epidural catheter and intermittent isotonic potassium chloride bolus in transversus abdominis plane catheter.
Intervention: Bupivacain-infusion in epidural catheter
Ropivacaine bolus in transversus abdominis plane catheter
Intermittent ropivacaine bolus in bilateral transversus abdominis plane catheter and isotonic potassium chloride infusion in epidural catheter.
Intervention: Ropivacaine bolus in transversus abdominis plane catheter
Outcomes
Primary Outcomes
Pain-score on numerical rating scale
Time Frame: 4 hours after first bolus in tranversus abdominis catheters
Secondary Outcomes
- Administration of opioids(The first 24 hours after surgery.)
- Pain-score on numerical rating scale(24 hours after first bolus in tranversus abdominis catheters)