Deciphering the Inflammatory Consequences of Crystalloids Used in the Resuscitation of Severely Burned Patients
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 14
- 试验地点
- 2
- 主要终点
- Change in monocyte phenotype from admission to day 10
研究概览
简要总结
This is a pilot study, but the investigators will also observe key immunological events with potential significance. The global objective is to study the inflammatory profiles of PlasmaLyte and Ringer's Lactate used in the initial massive fluid resuscitation of severely burned patients. On the long term, the investigators will identify the crystalloid that prevents hyperactivation of macrophages and death of severely burned patients.
详细描述
The investigators have 4 specific objectives. First, the investigators will compare the activation profiles of macrophages and neutrophils in patients admitted to the severely burned unit with regards to the crystalloids used. Secondly, the investigators will assess the differences in the SOFA scores according to the crystalloids used. Thirdly, the investigators will evaluate the impact of crystalloids in the quality of skin grafts performed on severely burned patients. Lastly, with the help of a patient partner, the investigators will determine the right immunological terminology of the study for a non-scientific population.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •admission to the CHUM
- •more than 20% of burned area
- •first blood withdrawal in the first 24 hours following burn
排除标准
- •immunosuppression
- •chemotherapy 6 months before admission
- •radiotherapy 6 months before admission
- •autoimmune diseases
- •neoplasia
- •pregnancy
- •severe infections
- •cardiac dysfunctions
- •renal dysfunction
- •hepatic dysfunctions
- •Hepatitis C
结局指标
主要结局
Change in monocyte phenotype from admission to day 10
时间窗: Pre-infusion to day 10 post-infusion
Following blood draws, monocytes will be subjected to flow cytometry for phenotype evaluation.
次要结局
未报告次要终点