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Clinical Trials/NCT03009149
NCT03009149UnknownPhase 1

Effects of Aerobic Exercise on CD4 Count,Viral Load,Selected Psycho-social Trait Among People Living With HIV/AIDS in Nekemte, Ethiopia

Mekelle University0 sites58 target enrollmentStarted: November 1, 2016Last updated:
Conditions
Interventions

Trial Snapshot

Phase
Phase 1
Enrollment
58
Primary Endpoint
Effects of aerobic exercise on psycho-social

Study Overview

Brief Summary

H1 - Aerobic exercise will expect to experience significant increase on CD4 counts , reduced viral load , improve psycho-social well being among people living with HIV /AIDS.

Detailed Description

Title - Effects of Aerobic Exercise on CD4(cluster of differentiation 4) count , Viral load and Selected Psycho-social Traits Among People Living with HIV/AIDS in Nekemte, Ethiopia

Human being have been challenged with different diseases from time to time. The cause of this diseases are virus , bacteria , fungi and etc. A diseases caused by virus , the Acquired Immune Deficiency Syndrome (AIDS) is very challenging to this century . By the end of 2008, UNAIDS/ world health organization (WHO) estimated that globally, a total of 33.4 million people were living with HIV, where by 31.3 million were adults. In sub-Saharan Africa, 22.4 million people were living with HIV in 2008 . Of these on 15.8 million were under anti-retro viral therapy (ART) to Jun, 2015 and 1.2 mill people died with AIDS related illnesses till end of the 2014 .

Aerobic fitness can improve the health of people living with many diseases, including HIV, and prevents muscle wasting . Exercise benefits may be include cytokine regulation, as is suggested in studies of autoimmune diseases such as multiple sclerosis. Aerobic exercise is one type of rehabilitation strategy that may be used to address disability, such as decreased strength and cardiovascular fitness for persons living with HIV . Exercise may also important to people living with virus because of its link to disease prevention and health promotion. Furthermore, aerobic exercise is creditable of attention because of its connection to body image, which has been shown to be important in certain populations affected by HIV.

This study will conduct in Nekemete town found in east Wollega zone , Oromia regional state. It will be a randomized controlled trial experimental research. The study design will pre-post of experimental clinical trial. Experimental trial will be with intervention of aerobic exercise among people living with HIV/AIDS under ART. The number of sample size is 58. Data analyses will perform with statical analysis for social science (SPSS) version 20. Descriptive data (means, standard deviations (SD) and standard error of the mean (SE), frequency, cross tabulation, charts) will calculate for all variables. The gender difference, viral load, CD4 count, data will analyze using simple t-test and analysis of co-variance (ANCOVA). The level of significance for all analyses will be set at P < 0.05.

Study Design

Study Type
Interventional
Allocation
Na
Intervention Model
Single Group
Primary Purpose
Supportive Care
Masking
None

Eligibility Criteria

Ages
30 Years to 40 Years (Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • •Both female and male under ART
  • •The distribution of HIV prevalence also varies by age peaking in the 30-40 years age group compared to the other (FDRE,2014) . Because of this the 30-40 will be selected.
  • •Participants who have been on first line antiretroviral therapy will be selected.
  • •Willing and able to give an informed and agree consent
  • •Free of HIV/AIDS related chronic infections that do not allowed aerobic exercise

Exclusion Criteria

  • •Participants with a history of central nervous system dysfunction, hemiparesis (paralysis of one side of the body).
  • •Diabetic patients
  • •Participant on either as prophylaxis such as the use of antibiotics to prevent infections or as part of (tuberculosis)TB treatment
  • •Pregnant and lactating women
  • •Free of risk factors those are series cardiac problem
  • •Participant who remain in study area throughout the period of study

Arms & Interventions

AEROBIC EXERCISE

Experimental

The effects of 12 week aerobic exercise will record

Intervention: Aerobic exercise (Other)

Outcomes

Primary Outcomes

Effects of aerobic exercise on psycho-social

Time Frame: 12 weeks

psycho-social will measure by stander questioner called WHOQOL-briff

CD4 count

Time Frame: 12 weeks

Amount of Cd4 will measure with in one ml blood sample

viral load change duo to aerobic exercise

Time Frame: 12 weeks

viral load will measured with in one milliliter of blood

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Girma Tilahun

PHD scholar

Mekelle University

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