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临床试验/NCT04439162
NCT04439162Unknown不适用

Results of Combined Antegrade and Retrograde Versurs Antegrade Cardioplegia in Complex Coronary Artery Bypass Surgeries

Assiut University0 个研究点目标入组 100 人开始时间: 2020年7月1日最近更新:
适应症

试验速览

阶段
不适用
入组人数
100
主要终点
myocardial function

研究概览

简要总结

During coronary artery bypass surgery, myocardial protection, especially of the right ventricle, may be inadequate in the presence of severe coronary lesions that obstruct the antegrade delivery of cold cardioplegia

详细描述

Asymetric myocardial cooling has been reported to yield postoperative right ventricular dysfunction, which may contribute to postoperative morbidity and mortality. Retrograde coronary sinus perfusion was introduced in 1956 to facilitate surgery involving the aortic valve. This technique was introduced as a means of myocardial protection for coronary artery bypass surgery in 1967 and has recently received renewed interest. An innovative method of delivering retrograde cardioplegia through the right atrium was recently developed by Fabiani and associates. This technique has obviated the need to directly cannulate the coronary sinus and thus has eliminated concerns regarding coronary sinus rupture due to cannulation, and concerns of inadequate right ventricular perfusion. In contrast to antegrade delivery, retrograde delivery of cardioplegia through the right atrium is not subject to the problem of limited distribution in the presence of coronary artery occlusive disease and thus allows more uniform cooling of the left ventricle,so the study will compare the results of combined antegrade and retrograde versurs antegrade cardioplegia in complex coronary artery bypass surgeries

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Screening
盲法
None

入排标准

年龄范围
18 Years 至 60 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Age between 18 and 60 years
  • LV ejection fraction between 30 and 50%
  • left main stem CAD
  • mitral or aortic valve disease associated with ischemic heart disease

排除标准

  • Double valve disease or other valve disease
  • mitral or aortic valve disease associated with congenital heart disease
  • patients subjected to prior heart surgery
  • emergency operation
  • poorly controlled diabetes mellitus

结局指标

主要结局

myocardial function

时间窗: two years

compare simultaneous antegrade-retrograde cardioplegia with antegrade cardioplegia in coronary artery surgeries in preservation of myocardial function by using transthoracic echocardiography examination postoperatively

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

El hussein Mohamed Abdelmotaleb Abdelhafez

associate lecteuer

Assiut University

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