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临床试验/CTRI/2024/02/062872
CTRI/2024/02/062872已完成4 期

Effect of zinc chloride mouthwash on oral mucositis in cancer patients undergoing chemotherapy- a randomized clinical trial

Dr L Krishna Prasad1 个研究点 分布在 1 个国家目标入组 42 人开始时间: 2024年3月5日最近更新:

试验速览

阶段
4 期
状态
已完成
发起方
入组人数
42
试验地点
1
主要终点
Oral mucositis score

研究概览

简要总结

subjects included were cancer patients under going chemotherapy from one oncology hospital of Guntur city, will be selected through purposive sampling. The subjects will be randomly categorized into two groups by a single investigator using block randomization. The groups are named as group A- mouthwash without zinc chloride (control group) (Listerine mouthwash- Alcohol, Benzoic Acid, Caramel, Methyl Salicylate, Poloxamer 407, Sodium Benzoate, Water (eau)) & group B- mouthwash containing zinc chloride (experimental group) (Lupident mouthwash- zinc chloride, chlorhexidine gluconate, sodium fluoride), containing 21 in each group. subjects included in the study will be selected by using inclusion and exclusion criteria. oral mucositis scores will be recorded by using world health organization criteria for grading of oral mucositis. baseline data of oral mucositis score will be obtained using clinical examination and mouthwash will be provided to the subjects included in the study. All subjects will be instructed to use mouth wash given to them accordingly (i.e; ZnCl mouthwash for experimental group and mouthwash without ZnCl) for every 8hrs for 2 weeks. At the end of 2 weeks all the subjects in both the groups will be examined for oral mucositis scores. Comparision of both the groups will be done using statistical test

研究设计

研究类型
Interventional
分配方式
Randomized
盲法
Participant, Investigator and Outcome Assessor Blinded

入排标准

年龄范围
20.00 Year(s) 至 60.00 Year(s)(—)
性别
All

入选标准

  • Cancer patients having oral mucositis following Chemotherapy after 24 hours.
  • Patients who provide consent form.

排除标准

  • Patients having any oral cancers Patients who are in critical condition Patients who are not willing to participate Patients having grade 0 oral mucositis score.

结局指标

主要结局

Oral mucositis score

时间窗: Baseline & after 2 weeks

次要结局

  • weight(Baseline & after 2 weeks)

研究者

发起方
Dr L Krishna Prasad
申办方类型
Other [self]
责任方
Principal Investigator
主要研究者

K Bhargavi

sibar institute of dental sciences

研究点 (1)

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