Effects of Cardiorespiratory Rehabilitation on the Right Ventricle in Pulmonary Hypertension

Not Applicable

Completed

• Conditions: Pulmonary Hypertension
• Interventions: Other: Stress echocardiography

• Registration Number: NCT03404492
• Lead Sponsor: Centre Hospitalier Universitaire de Nice

Brief Summary

Clinical improvement has been demonstrated after cardiorespiratory rehabilitation in patients with pulmonary hypertension. Rehabilitation is therefore now part of the recommendations for good practice. However, no data is available to elucidate the mechanism of this improvement: an improvement in myocardial reserve or an improvement in peripheral muscular capacity? The main objective of this study is to evaluate the difference in right ventricular contractile reserve before and after cardiorespiratory rehabilitation during stress ultrasound in pulmonary hypertension in 10 patients with pulmonary hypertension.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2018-01-12
• Study First Submitted QC: 2018-01-12
• Study First Posted: 2018-01-19
• Study Start: 2018-06-12
• Primary Completion: 2019-07-05
• Study Completion: 2020-07-05
• Status Verified: 2023-08
• Last Update Submitted: 2023-08-28
• Last Update Posted: 2023-08-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• Major patients
• Proven pulmonary hypertension: PAPm ≥ 25mmHg, known PH
• Group 1,3,4 or 5 of the pulmonary hypertension classification
• Clinical stability > 1 month clinically determined by clinician
• NYHA II or III class
• Signature of informed consent form following appropriate information
• Patient affiliated to the Social Security System

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Exclusion Criteria

• Associated left heart disease
• Complex congenital heart disease
• Acoustic window which does not allow the echocardiography to be performed correctly
• Permanent cardiac arrhythmia
• NYHA IV class and NYHA I class
• Inability to perform at least a minimal effort on an ergometer
• Unstabilized acute coronary syndrome
• Compensatory heart failure
• Disturbances of ventricular rhythm veins, may not be narrowed.
• Prevalence of high-risk embolic intracardiac thrombus
• Prevalence of high-risk embolic intracardiac thrombus
• Preference of a medium to high abundance peericard-like thinning.
• Venous thromboembolic venous thromboembolic disease (> 3 months)
• Left ventricular ejector obstruction (severe and/or symptomatic)
• Persons under guardianship, under curatorship, protected by law
• Persons deprived of their liberty
• Pregnant and parturient women
• Major not able or unable to express consent
• Minors
• Inability to perform cardiac rehabilitation
• Modynamic instability
• Follow-up impossible for geographical or psychological reasons
• Inadequate command of the French language

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Patients with pulmonary hypertension	Stress echocardiography	-

Primary Outcome Measures

Name	Time	Method
Improvement of the subpulmonary ITS at effort >20% (presence of a right ventricular contractile reserve) defined by the improvement of the ITS or integral subpulmonary time-speed)	4 months

Trial Locations

Locations (1)

Hôpital Pasteur; 🇫🇷 Nice, France