Study in ICU Patients Regarding Protein Intake and CT-derived Body Composition
- Conditions
- Muscular Atrophy
- Interventions
- Other: Computed tomography scan made for clinical reasonsDietary Supplement: Nutrition as per hospital protocol
- Registration Number
- NCT02817646
- Lead Sponsor
- Amsterdam UMC, location VUmc
- Brief Summary
The purpose of this study is to determine whether protein intake during the first days of intensive care admission, in relation to body composition at intensive care admission as assessed on computed tomography scans made during routine care, is are related to clinical outcome in critically ill patients.
- Detailed Description
Optimal protein and energy intake have been shown to be relevant for reducing mortality in prospective observational studies in mechanically ventilated patients admitted to the intensive care unit. However, nutritional status (protein mass, muscle mass) of patients at admission and possible consequences for clinical outcome are largely unknown. Computerized tomography scans can be used to assess muscle mass as a proxy for body protein mass.
The investigators are especially interested in the effect of protein intake on clinical outcome in intensive care patients with different body protein mass at admission. This is relevant for appropriate formulation of clinical (protein) nutrition in this patient group. Therefore, the relationship between protein intake and patient outcome is evaluated in intensive care patients with low muscle and normal muscle area, using muscle area from computed tomography scans as a proxy of body protein mass.
Additionally, data from computed tomography scans regarding muscle quality and muscle- and fat quantity are used to evaluate the prognostic value of body composition at intensive care admission. Finally, abdominal computed tomography scans are compared with thoracic computed tomography scans.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 800
- Abdominal computed tomography scan made 1 day before up to 4 days after admission to the intensive care unit
- Length of intensive care stay of at least 4 days
- Mechanical ventilation during intensive care stay
- Computed tomography scan not eligible for analysis
- Missing data
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Intensive care patients Nutrition as per hospital protocol Patients admitted to the intensive care unit for 4 days or more with a computed tomography scan made for clinical reasons early during intensive care stay and who receive enteral and/or parenteral nutrition as per hospital protocol Intensive care patients Computed tomography scan made for clinical reasons Patients admitted to the intensive care unit for 4 days or more with a computed tomography scan made for clinical reasons early during intensive care stay and who receive enteral and/or parenteral nutrition as per hospital protocol
- Primary Outcome Measures
Name Time Method All-cause mortality From admission to the intensive care unit untill discharge from the hospital, an average of one month
- Secondary Outcome Measures
Name Time Method Percentage of patients discharged to home After discharge from the hospital, on average after one month Length of hospital stay (days) The total duration of admission to the hospital, an average of one month Length of intensive care unit stay The total duration of admission to the intensive care unit, an average of two weeks Length of ventilation The total duration of mechanical ventilation during intensive care unit stay, an average of 10 days