Investigation The Effect of Conventional Vs. Individualized Transcranial Direct Current Stimulation Intensity to Achieve Uniform E-Fields
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 30
- 主要终点
- Transcranial Magnetic Stimulation (TMS) Assessment
研究概览
简要总结
Background: Replications of studies employing transcranial direct stimulation (tDCS) shows great variations in physiological and behavioral outcomes. The disparity between studies is based on the expectations of getting the same cortical activity changes consistently once the procedures and current parameters have been repeated. Nevertheless, this assumption was inoperative, due to the individualized variations of numerous parameters such as: age, disease type, symptom severity, head geometry, etc.
Objective: Through this clinical trial we aim to reduce the variability of the physiological and behavioral outcomes of tDCS by individualizing the current intensity and to study the neurophysiological and behavioral outcome differences between participants who receive the customized current intensity in comparison to the others who would receive a fixed dose.
Methods: Based on individual patient's structural MRI images, the Electrical field (E-field) distribution can be modeled and the individualized current dose to stimulate a target region can be determined. A group of thirty persons with multiple sclerosis (PWMS) would be pseudo-randomized into three groups receiving all 3 treatments of individualized tDCS, fixed currents (2 mA), and sham tDCS. Baseline and post-intervention assessment of physiological and behavioral outcome measures will be assessed using respectively, transcranial magnetic stimulation (TMS) recruitment curve and a stop-signal task and GO/No-go test.
Significant statement and clinical relevance: Individualizing the patient's tDCS current intensity will result in a better clinical outcome (i.e. more robust physiological and behavioral effects), as compared to a tDCS application that is based on a fixed current.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Screening
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Right-handed volunteers, assessed by Edinburgh handedness inventory
- •Normal or corrected-to-normal vision
- •Greater than or equal to 18 years old
- •Relapsing-remitting type of MS (RRMS)
- •Moderate disability EDSS score ≤ 6.5
- •Free of relapsing attack at least a month before recruitment
排除标准
- •Subject recently had a seizure or epilepsy
- •Subject is a habitual smoker;
- •Subject has a history of any major disease that may interfere with the investigations (especially liver and kidney disease, upper limb pathologies, history of significant multiple traumas, or diabetes) or cancer;
- •Subject has any history of a major neurological disorder in addition to MS (including previous severe brain trauma and cognitive impairment) or known cerebral structural abnormalities;
- •Subject has a diagnosed mental disorder (e.g., depression, bipolar disorder, schizophrenia, psychoses);
- •Subject is currently a user (including ''recreational use'') of any illicit drugs or has a history of drug or alcohol abuse;
- •Subject has significant abnormalities on T1/T2 MRI scan;
- •Subject has a contra-indication for MRI scanning or TMS measurements (see screening forms for MRI and TMS);
- •Subject does not understand the study procedure;
- •Subject is unwilling or unable to perform all study procedures, or is considered unsuitable in any way by the principal investigator;
- •Subject is not able to perform the motor tasks;
- •Subject is (potentially) pregnant (in case of doubt, hCG test will be conducted in female participants); subject is breastfeeding at the time of the study;
- •Subject chronically uses medication, especially sedatives or sleep medication (contraceptives allowed). Other medication that is only taken as needed will be allowed at the investigator's discretion;
- •Using TMS, no (sufficiently stable) MEPs can be evoked at left M1;
结局指标
主要结局
Transcranial Magnetic Stimulation (TMS) Assessment
时间窗: Baseline assessment before tDCS session (Pre-intervention), and immediately following tDCS session (Post-intervention).
Changes in cortical excitability will be measured by single and paired TMS pulses. The final values will be assessed for improvements.
次要结局
- Behavioral Assessment(Baseline assessment before tDCS session (Pre-intervention), and immediately following tDCS session (Post-intervention).)
研究者
Koen Cuypers
Assoc. Prof.
Hasselt University