Factors Influencing of Pulse Pressure Variation (PPV)

Completed

• Conditions: Fluid Responsiveness; Haemodynamics; Pulse Pressure Variation
• Interventions: Device: Patients were ventilated with assist-control ventilation（A/C） mode at different tidal volume; Behavioral: spontaneous breathing and no spontaneous breathing

• Registration Number: NCT04802668
• Lead Sponsor: Southeast University, China

Brief Summary

The investigators studied the predictive value of PPV in the patients with different influencing factors;and the method to improve the predictive value,which can improve the application of PPV in ICU.

Detailed Description

PPV can be used to predict fluid responsiveness in patients with circulatory shock.However, it is affected by many factors, which leads to the decrease of the applicability of PPV in ICU.Therefore, the investigators studied the predictive value of PPV in the patients with different influencing factors;and the method to improve the predictive value,which can improve the application of PPV in ICU.

Study Timeline

• Study First Submitted: 2021-02-06
• Study First Submitted QC: 2021-03-15
• Study First Posted: 2021-03-17
• Study Start: 2021-03-20
• Primary Completion: 2022-03-30
• Study Completion: 2022-07-30
• Status Verified: 2023-01
• Last Update Submitted: 2023-01-07
• Last Update Posted: 2023-01-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 189

Inclusion Criteria

• Patients requiring invasive mechanical ventilation
• Acute circulatory failure,defined as:systolic blood pressure <90 mmHg or blood pressure in patients with previous hypertension lower than the baseline value> 40 mmHg; vasoactive drugs are required to maintain blood pressure (mean arterial pressure> 65 mmHg); with or without signs of hypoperfusion (oliguria<0.5ml.kg-1.h-1 for at least 2 hours; arterial blood lactic acid>2.5mmol.L-1; skin mottling)

Exclusion Criteria

• The age of the patient is less than 18 years old or more than 80 years old
• Refuse to sign the informed consent to join the group
• Atrial fibrillation and other arrhythmias that seriously affect the output per beat;
• With pregnancy
• Other situations where the clinician believes that the patient is not suitable for inclusion in the study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Circulatory failure patients	spontaneous breathing and no spontaneous breathing	Circulatory failure patients requiring fluid responsiveness evaluation
Circulatory failure patients	Patients were ventilated with assist-control ventilation（A/C） mode at different tidal volume	Circulatory failure patients requiring fluid responsiveness evaluation

Primary Outcome Measures

Name	Time	Method
cardiac output(CO)	1 day	The measurement of cardiac output(CO);

Secondary Outcome Measures

Name	Time	Method
measurement of Hemodynamic variables from the monitor;	1 day	The investigators record the hemodynamic variables from the monitor MAP and CVP
measurement of airway pressure variables from ventilator	1 day	The investigators record the airway pressure variables during the inspiration and expiration from the ventilator
Pocc	1 day	delta change of airway pressure during expiratory occlusion in different interventions.
measurement of Pulse pressure variation（PPV）from monitor;	Research period	Pulse pressure variation (PPV)(percent) ,whic is calculated from the systolic and diastolic blood pressure,can be read from the monitor directly.
P 0.1	1 day	airway occlusion pressure at 100 milliseconds after the onset of inspiration (P0.1)(cmH2O)

Trial Locations

Locations (1)

Ling Liu; 🇨🇳 Nanjing, Jiangsu, China